Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

G. Colella; M. Pennati; A. Bearzatto; R. Leone; D. Colangelo; C. Manzotti; M. G. Daidone; N. Zaffaroni

doi:10.1054/bjoc.2001.1751

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

G. Colella, M. Pennati, A. Bearzatto, R. Leone, D. Colangelo, C. Manzotti, M. G. Daidone, N. Zaffaroni

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

Lingua originale	Inglese
pagine (da-a)	1387-1390
Numero di pagine	4
Rivista	British Journal of Cancer
Volume	84
Numero di pubblicazione	10
DOI	https://doi.org/10.1054/bjoc.2001.1751
Stato di pubblicazione	Pubblicato - 18 mag 2001
Pubblicato esternamente	Sì

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10.1054/bjoc.2001.1751

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Colella, G., Pennati, M., Bearzatto, A., Leone, R., Colangelo, D., Manzotti, C., Daidone, M. G., & Zaffaroni, N. (2001). Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions. British Journal of Cancer, 84(10), 1387-1390. https://doi.org/10.1054/bjoc.2001.1751

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title = "Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions",

abstract = "A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.",

keywords = "BBR 3464, Cisplatin, DNA repair, Ovarian cancer",

author = "G. Colella and M. Pennati and A. Bearzatto and R. Leone and D. Colangelo and C. Manzotti and Daidone, {M. G.} and N. Zaffaroni",

year = "2001",

month = may,

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doi = "10.1054/bjoc.2001.1751",

language = "English",

volume = "84",

pages = "1387--1390",

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Colella, G, Pennati, M, Bearzatto, A, Leone, R, Colangelo, D, Manzotti, C, Daidone, MG & Zaffaroni, N 2001, 'Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions', British Journal of Cancer, vol. 84, n. 10, pagg. 1387-1390. https://doi.org/10.1054/bjoc.2001.1751

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions. / Colella, G.; Pennati, M.; Bearzatto, A. et al.
In: British Journal of Cancer, Vol. 84, N. 10, 18.05.2001, pag. 1387-1390.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin

T2 - Cytotoxicity and induction and gene-specific repair of DNA lesions

AU - Colella, G.

AU - Pennati, M.

AU - Bearzatto, A.

AU - Leone, R.

AU - Colangelo, D.

AU - Manzotti, C.

AU - Daidone, M. G.

AU - Zaffaroni, N.

PY - 2001/5/18

Y1 - 2001/5/18

N2 - A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

AB - A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

KW - BBR 3464

KW - Cisplatin

KW - DNA repair

KW - Ovarian cancer

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U2 - 10.1054/bjoc.2001.1751

DO - 10.1054/bjoc.2001.1751

M3 - Article

SN - 0007-0920

VL - 84

SP - 1387

EP - 1390

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

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