Accelerating water exchange in GdIII-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

Loredana Leone; David Esteban-Gómez; Carlos Platas-Iglesias; Marco Milanesio; Lorenzo Tei

doi:10.1039/c8cc08556k

Accelerating water exchange in Gd^III-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

Loredana Leone, David Esteban-Gómez, Carlos Platas-Iglesias, Marco Milanesio, Lorenzo Tei

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The Gd^III-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.

Lingua originale	Inglese
pagine (da-a)	513-516
Numero di pagine	4
Rivista	Chemical Communications
Volume	55
Numero di pubblicazione	4
DOI	https://doi.org/10.1039/c8cc08556k
Stato di pubblicazione	Pubblicato - 2019

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10.1039/c8cc08556k

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title = "Accelerating water exchange in GdIII-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding",

abstract = "The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.",

author = "Loredana Leone and David Esteban-G{\'o}mez and Carlos Platas-Iglesias and Marco Milanesio and Lorenzo Tei",

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doi = "10.1039/c8cc08556k",

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AU - Milanesio, Marco

AU - Tei, Lorenzo

PY - 2019

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AB - The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.

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DO - 10.1039/c8cc08556k

M3 - Article

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JO - Chemical Communications

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Accelerating water exchange in GdIII-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

Abstract

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Accelerating water exchange in Gd^III-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding