Absolute configuration of the fungal metabolite spirolaxine

Adriana Bava; Marco Clericuzio; Giuseppe Giannini; Luciana Malpezzi; Stefano Valdo Meille; Gianluca Nasini

doi:10.1002/ejoc.200400902

Absolute configuration of the fungal metabolite spirolaxine

Adriana Bava
, Marco Clericuzio
, Giuseppe Giannini
, Luciana Malpezzi
, Stefano Valdo Meille
, Gianluca Nasini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations.

Lingua originale	Inglese
pagine (da-a)	2292-2296
Numero di pagine	5
Rivista	European Journal of Organic Chemistry
Numero di pubblicazione	11
DOI	https://doi.org/10.1002/ejoc.200400902
Stato di pubblicazione	Pubblicato - 30 mag 2005
Pubblicato esternamente	Sì

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10.1002/ejoc.200400902

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title = "Absolute configuration of the fungal metabolite spirolaxine",

abstract = "The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations.",

keywords = "Absolute configuration, Angiogenesis, Basidiomycetes, Circular dichroism, Secondary metabolite, Spiro compounds",

author = "Adriana Bava and Marco Clericuzio and Giuseppe Giannini and Luciana Malpezzi and Meille, \{Stefano Valdo\} and Gianluca Nasini",

year = "2005",

month = may,

day = "30",

doi = "10.1002/ejoc.200400902",

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journal = "European Journal of Organic Chemistry",

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T1 - Absolute configuration of the fungal metabolite spirolaxine

AU - Bava, Adriana

AU - Clericuzio, Marco

AU - Giannini, Giuseppe

AU - Malpezzi, Luciana

AU - Meille, Stefano Valdo

AU - Nasini, Gianluca

PY - 2005/5/30

Y1 - 2005/5/30

N2 - The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations.

AB - The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations.

KW - Absolute configuration

KW - Angiogenesis

KW - Basidiomycetes

KW - Circular dichroism

KW - Secondary metabolite

KW - Spiro compounds

UR - https://www.scopus.com/pages/publications/20444494848

U2 - 10.1002/ejoc.200400902

DO - 10.1002/ejoc.200400902

M3 - Article

SN - 1434-193X

SP - 2292

EP - 2296

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 11

ER -

Absolute configuration of the fungal metabolite spirolaxine

Abstract

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