AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents

Giuseppe Gugliotta, Mauro Botta, Lorenzo Tei

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-GdIII complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.

Lingua originaleInglese
pagine (da-a)4569-4574
Numero di pagine6
RivistaOrganic and Biomolecular Chemistry
Volume8
Numero di pubblicazione20
DOI
Stato di pubblicazionePubblicato - 21 ott 2010

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