Abstract
Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-GdIII complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.
Lingua originale | Inglese |
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pagine (da-a) | 4569-4574 |
Numero di pagine | 6 |
Rivista | Organic and Biomolecular Chemistry |
Volume | 8 |
Numero di pubblicazione | 20 |
DOI | |
Stato di pubblicazione | Pubblicato - 21 ott 2010 |