AAZTA: An Ideal Chelating Agent for the Development of44Sc PET Imaging Agents

Gábor Nagy; Dezső Szikra; György Trencsényi; Anikó Fekete; Ildikó Garai; Arianna M. Giani; Roberto Negri; Norberto Masciocchi; Alessandro Maiocchi; Fulvio Uggeri; Imre Tóth; Silvio Aime; Giovanni B. Giovenzana; Zsolt Baranyai

doi:10.1002/anie.201611207

AAZTA: An Ideal Chelating Agent for the Development of⁴⁴Sc PET Imaging Agents

Gábor Nagy, Dezső Szikra, György Trencsényi, Anikó Fekete, Ildikó Garai, Arianna M. Giani, Roberto Negri, Norberto Masciocchi, Alessandro Maiocchi, Fulvio Uggeri, Imre Tóth, Silvio Aime, Giovanni B. Giovenzana, Zsolt Baranyai

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Unprecedented fast and efficient complexation of Sc^IIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the⁴⁴Sc(AAZTA)⁻chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.

Lingua originale	Inglese
pagine (da-a)	2118-2122
Numero di pagine	5
Rivista	Angewandte Chemie - International Edition
Volume	56
Numero di pubblicazione	8
DOI	https://doi.org/10.1002/anie.201611207
Stato di pubblicazione	Pubblicato - 13 feb 2017

Accesso al documento

10.1002/anie.201611207

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Cita questo

Nagy, G., Szikra, D., Trencsényi, G., Fekete, A., Garai, I., Giani, A. M., Negri, R., Masciocchi, N., Maiocchi, A., Uggeri, F., Tóth, I., Aime, S., Giovenzana, G. B., & Baranyai, Z. (2017). AAZTA: An Ideal Chelating Agent for the Development of⁴⁴Sc PET Imaging Agents. Angewandte Chemie - International Edition, 56(8), 2118-2122. https://doi.org/10.1002/anie.201611207

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title = "AAZTA: An Ideal Chelating Agent for the Development of44Sc PET Imaging Agents",

abstract = "Unprecedented fast and efficient complexation of ScIIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the44Sc(AAZTA)−chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.",

keywords = "PET, kinetics, radiopharmaceuticals, scandium, thermodynamics",

author = "G{\'a}bor Nagy and Dezs{\H o} Szikra and Gy{\"o}rgy Trencs{\'e}nyi and Anik{\'o} Fekete and Ildik{\'o} Garai and Giani, \{Arianna M.\} and Roberto Negri and Norberto Masciocchi and Alessandro Maiocchi and Fulvio Uggeri and Imre T{\'o}th and Silvio Aime and Giovenzana, \{Giovanni B.\} and Zsolt Baranyai",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2017",

month = feb,

day = "13",

doi = "10.1002/anie.201611207",

language = "English",

volume = "56",

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journal = "Angewandte Chemie - International Edition",

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TY - JOUR

T1 - AAZTA

T2 - An Ideal Chelating Agent for the Development of44Sc PET Imaging Agents

AU - Nagy, Gábor

AU - Szikra, Dezső

AU - Trencsényi, György

AU - Fekete, Anikó

AU - Garai, Ildikó

AU - Giani, Arianna M.

AU - Negri, Roberto

AU - Masciocchi, Norberto

AU - Maiocchi, Alessandro

AU - Uggeri, Fulvio

AU - Tóth, Imre

AU - Aime, Silvio

AU - Giovenzana, Giovanni B.

AU - Baranyai, Zsolt

PY - 2017/2/13

Y1 - 2017/2/13

N2 - Unprecedented fast and efficient complexation of ScIIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the44Sc(AAZTA)−chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.

AB - Unprecedented fast and efficient complexation of ScIIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the44Sc(AAZTA)−chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.

KW - PET

KW - kinetics

KW - radiopharmaceuticals

KW - scandium

KW - thermodynamics

UR - https://www.scopus.com/pages/publications/85009766693

U2 - 10.1002/anie.201611207

DO - 10.1002/anie.201611207

M3 - Article

SN - 1433-7851

VL - 56

SP - 2118

EP - 2122

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 8