AAZTA: An Ideal Chelating Agent for the Development of44Sc PET Imaging Agents

Gábor Nagy, Dezső Szikra, György Trencsényi, Anikó Fekete, Ildikó Garai, Arianna M. Giani, Roberto Negri, Norberto Masciocchi, Alessandro Maiocchi, Fulvio Uggeri, Imre Tóth, Silvio Aime, Giovanni B. Giovenzana, Zsolt Baranyai

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Unprecedented fast and efficient complexation of ScIIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the44Sc(AAZTA)chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.

Lingua originaleInglese
pagine (da-a)2118-2122
Numero di pagine5
RivistaAngewandte Chemie - International Edition
Volume56
Numero di pubblicazione8
DOI
Stato di pubblicazionePubblicato - 13 feb 2017

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