Abstract
Unprecedented fast and efficient complexation of ScIIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the44Sc(AAZTA)−chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
Lingua originale | Inglese |
---|---|
pagine (da-a) | 2118-2122 |
Numero di pagine | 5 |
Rivista | Angewandte Chemie - International Edition |
Volume | 56 |
Numero di pubblicazione | 8 |
DOI | |
Stato di pubblicazione | Pubblicato - 13 feb 2017 |