A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

Maria Liguori; Stephen Sawcer; Efrosini Setakis; Alastair Compston; Mara Giordano; Sandra D'Alfonso; Marta Mellai; Giulia Malferrari; Maria Trojano; Paolo Livrea; Francesca De Robertis; Luca Massacesi; Anna Repice; Clara Ballerini; Tiziana Biagioli; Roberto Bomprezzi; Stefania Cannoni; Giovanni Ristori; Marco Salvetti; Luigi M.E. Grimaldi; Ida Biunno; Giancarlo Comi; Maurizio Leone; Isabella Ferro; Paola Naldi; Clara Milanese; Cinzia Gellera; La Mantia Loredana; Giovanni Savettieri; Giuseppe Salemi; Paolo Aridon; Domenico Caputo; Franca Rosa Guerini; Pasquale Ferrante; Patricia Momigliano-Richiardi

doi:10.1016/j.jneuroim.2003.08.020

A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

Maria Liguori, Stephen Sawcer, Efrosini Setakis, Alastair Compston, Mara Giordano, Sandra D'Alfonso, Marta Mellai, Giulia Malferrari, Maria Trojano, Paolo Livrea, Francesca De Robertis, Luca Massacesi, Anna Repice, Clara Ballerini, Tiziana Biagioli, Roberto Bomprezzi, Stefania Cannoni, Giovanni Ristori, Marco Salvetti, Luigi M.E. GrimaldiIda Biunno, Giancarlo Comi, Maurizio Leone, Isabella Ferro, Paola Naldi, Clara Milanese, Cinzia Gellera, La Mantia Loredana, Giovanni Savettieri, Giuseppe Salemi, Paolo Aridon, Domenico Caputo, Franca Rosa Guerini, Pasquale Ferrante, Patricia Momigliano-Richiardi

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.

Lingua originale	Inglese
pagine (da-a)	97-100
Numero di pagine	4
Rivista	Journal of Neuroimmunology
Volume	143
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/j.jneuroim.2003.08.020
Stato di pubblicazione	Pubblicato - ott 2003

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10.1016/j.jneuroim.2003.08.020

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Liguori, M., Sawcer, S., Setakis, E., Compston, A., Giordano, M., D'Alfonso, S., Mellai, M., Malferrari, G., Trojano, M., Livrea, P., De Robertis, F., Massacesi, L., Repice, A., Ballerini, C., Biagioli, T., Bomprezzi, R., Cannoni, S., Ristori, G., Salvetti, M., ... Momigliano-Richiardi, P. (2003). A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. Journal of Neuroimmunology, 143(1-2), 97-100. https://doi.org/10.1016/j.jneuroim.2003.08.020

@article{a27b02f06b6a4e728a69ba20cf221e8d,

title = "A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population",

abstract = "We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.",

keywords = "DNA pools, Microsatellites, Multiple sclerosis, Whole genome linkage disequilibrium",

author = "Maria Liguori and Stephen Sawcer and Efrosini Setakis and Alastair Compston and Mara Giordano and Sandra D'Alfonso and Marta Mellai and Giulia Malferrari and Maria Trojano and Paolo Livrea and \{De Robertis\}, Francesca and Luca Massacesi and Anna Repice and Clara Ballerini and Tiziana Biagioli and Roberto Bomprezzi and Stefania Cannoni and Giovanni Ristori and Marco Salvetti and Grimaldi, \{Luigi M.E.\} and Ida Biunno and Giancarlo Comi and Maurizio Leone and Isabella Ferro and Paola Naldi and Clara Milanese and Cinzia Gellera and Loredana, \{La Mantia\} and Giovanni Savettieri and Giuseppe Salemi and Paolo Aridon and Domenico Caputo and Guerini, \{Franca Rosa\} and Pasquale Ferrante and Patricia Momigliano-Richiardi",

note = "Funding Information: This study represents one component of the GAMES project designed and co-ordinated by DASC and SJS (Cambridge, UK.) with funding from the Wellcome Trust (grant 057097) supplemented by the Multiple Sclerosis Societies of the United States and Great Britain, and MS International Federation. Funding Information: We acknowledge FISM (Italian Foundation for Multiple Sclerosis) for the support to the Florence DNA bank and for donating the Robotic Liquid Multihandling System (Multiprobe II, Packard). ",

year = "2003",

month = oct,

doi = "10.1016/j.jneuroim.2003.08.020",

language = "English",

volume = "143",

pages = "97--100",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

number = "1-2",

}

Liguori, M, Sawcer, S, Setakis, E, Compston, A, Giordano, M , D'Alfonso, S, Mellai, M, Malferrari, G, Trojano, M, Livrea, P, De Robertis, F, Massacesi, L, Repice, A, Ballerini, C, Biagioli, T, Bomprezzi, R, Cannoni, S, Ristori, G, Salvetti, M, Grimaldi, LME, Biunno, I, Comi, G, Leone, M, Ferro, I, Naldi, P, Milanese, C, Gellera, C, Loredana, LM, Savettieri, G, Salemi, G, Aridon, P, Caputo, D, Guerini, FR, Ferrante, P & Momigliano-Richiardi, P 2003, 'A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population', Journal of Neuroimmunology, vol. 143, n. 1-2, pagg. 97-100. https://doi.org/10.1016/j.jneuroim.2003.08.020

TY - JOUR

T1 - A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

AU - Liguori, Maria

AU - Sawcer, Stephen

AU - Setakis, Efrosini

AU - Compston, Alastair

AU - Giordano, Mara

AU - D'Alfonso, Sandra

AU - Mellai, Marta

AU - Malferrari, Giulia

AU - Trojano, Maria

AU - Livrea, Paolo

AU - De Robertis, Francesca

AU - Massacesi, Luca

AU - Repice, Anna

AU - Ballerini, Clara

AU - Biagioli, Tiziana

AU - Bomprezzi, Roberto

AU - Cannoni, Stefania

AU - Ristori, Giovanni

AU - Salvetti, Marco

AU - Grimaldi, Luigi M.E.

AU - Biunno, Ida

AU - Comi, Giancarlo

AU - Leone, Maurizio

AU - Ferro, Isabella

AU - Naldi, Paola

AU - Milanese, Clara

AU - Gellera, Cinzia

AU - Loredana, La Mantia

AU - Savettieri, Giovanni

AU - Salemi, Giuseppe

AU - Aridon, Paolo

AU - Caputo, Domenico

AU - Guerini, Franca Rosa

AU - Ferrante, Pasquale

AU - Momigliano-Richiardi, Patricia

N1 - Funding Information: This study represents one component of the GAMES project designed and co-ordinated by DASC and SJS (Cambridge, UK.) with funding from the Wellcome Trust (grant 057097) supplemented by the Multiple Sclerosis Societies of the United States and Great Britain, and MS International Federation. Funding Information: We acknowledge FISM (Italian Foundation for Multiple Sclerosis) for the support to the Florence DNA bank and for donating the Robotic Liquid Multihandling System (Multiprobe II, Packard).

PY - 2003/10

Y1 - 2003/10

N2 - We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.

AB - We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.

KW - DNA pools

KW - Microsatellites

KW - Multiple sclerosis

KW - Whole genome linkage disequilibrium

UR - http://www.scopus.com/inward/record.url?scp=10744220450&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2003.08.020

DO - 10.1016/j.jneuroim.2003.08.020

M3 - Article

SN - 0165-5728

VL - 143

SP - 97

EP - 100

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

Abstract

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