A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids

Mariateresa Giustiniano, Sveva Pelliccia, Ubaldina Galli, Jussara Amato, Fabio Travagin, Ettore Novellino, Gian Cesare Tron

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Old multicomponent reactions are still a source of inspiration for discovering novel combinations of three or more reactants. A simple idea is to replace one of the educts of a known multicomponent reaction with another functional group and still be able to mimic the same reactivity. Following this line of thought, we report a three-component reaction in which isocyanides are able to open the epoxide intermediate of the Bargellini reaction affording 3-carboxamido-isobutyric acids in yields of 47-95%.

Lingua originaleInglese
pagine (da-a)11467-11471
Numero di pagine5
RivistaJournal of Organic Chemistry
Volume81
Numero di pubblicazione22
DOI
Stato di pubblicazionePubblicato - 18 nov 2016

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