TY - JOUR
T1 - A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction
T2 - Synthesis of 3-Carboxamido-Isobutyric Acids
AU - Giustiniano, Mariateresa
AU - Pelliccia, Sveva
AU - Galli, Ubaldina
AU - Amato, Jussara
AU - Travagin, Fabio
AU - Novellino, Ettore
AU - Tron, Gian Cesare
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/11/18
Y1 - 2016/11/18
N2 - Old multicomponent reactions are still a source of inspiration for discovering novel combinations of three or more reactants. A simple idea is to replace one of the educts of a known multicomponent reaction with another functional group and still be able to mimic the same reactivity. Following this line of thought, we report a three-component reaction in which isocyanides are able to open the epoxide intermediate of the Bargellini reaction affording 3-carboxamido-isobutyric acids in yields of 47-95%.
AB - Old multicomponent reactions are still a source of inspiration for discovering novel combinations of three or more reactants. A simple idea is to replace one of the educts of a known multicomponent reaction with another functional group and still be able to mimic the same reactivity. Following this line of thought, we report a three-component reaction in which isocyanides are able to open the epoxide intermediate of the Bargellini reaction affording 3-carboxamido-isobutyric acids in yields of 47-95%.
UR - http://www.scopus.com/inward/record.url?scp=84996490349&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.6b02130
DO - 10.1021/acs.joc.6b02130
M3 - Article
SN - 0022-3263
VL - 81
SP - 11467
EP - 11471
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 22
ER -