A short intramolecular Diels-Alder route to himbacine derivatives

Sven Hofman, Ling Jie Gao, Hilde Van Dingenen, Noël G.C. Hosten, Dirk Van Haver, Pierre J. De Clercq, Marco Milanesio, Davide Viterbo

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The intramolecular cycloaddition of 5 yields the unsaturated lactones 17a, 17b, and 17c as three major isomeric adducts. These were further reduced to the corresponding derivatives 21a, 21b, and 21c, which are intermediates for the synthesis of (+)-himbacine and stereoisomers thereof. Precursor 5 was obtained in a short convergent way using Sonogashira and Stille coupling reactions as the main C-C bond construction reactions.

Lingua originaleInglese
pagine (da-a)2851-2860
Numero di pagine10
RivistaEuropean Journal of Organic Chemistry
Numero di pubblicazione15
DOI
Stato di pubblicazionePubblicato - ago 2001
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'A short intramolecular Diels-Alder route to himbacine derivatives'. Insieme formano una fingerprint unica.

Cita questo