A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging

Valeria Catanzaro; Concetta V. Gringeri; Valeria Menchise; Sergio Padovan; Cinzia Boffa; Walter Dastrù; Linda Chaabane; Giuseppe Digilio; Silvio Aime

doi:10.1002/anie.201209286

A R_2p/R_1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging

Valeria Catanzaro
, Concetta V. Gringeri
, Valeria Menchise
, Sergio Padovan
, Cinzia Boffa
, Walter Dastrù
, Linda Chaabane
, Giuseppe Digilio
, Silvio Aime

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R _2p/R_1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

Lingua originale	Inglese
pagine (da-a)	3926-3930
Numero di pagine	5
Rivista	Angewandte Chemie - International Edition
Volume	52
Numero di pubblicazione	14
DOI	https://doi.org/10.1002/anie.201209286
Stato di pubblicazione	Pubblicato - 2 apr 2013

Accesso al documento

10.1002/anie.201209286

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{24a79f2eec8f48a687a1f10c9b715108,

title = "A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging",

abstract = "Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.",

keywords = "MRI probe, gadolinium, liposome, matrix metalloproteinases, molecular imaging",

author = "Valeria Catanzaro and Gringeri, \{Concetta V.\} and Valeria Menchise and Sergio Padovan and Cinzia Boffa and Walter Dastr{\`u} and Linda Chaabane and Giuseppe Digilio and Silvio Aime",

year = "2013",

month = apr,

day = "2",

doi = "10.1002/anie.201209286",

language = "English",

volume = "52",

pages = "3926--3930",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "14",

}

TY - JOUR

T1 - A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging

AU - Catanzaro, Valeria

AU - Gringeri, Concetta V.

AU - Menchise, Valeria

AU - Padovan, Sergio

AU - Boffa, Cinzia

AU - Dastrù, Walter

AU - Chaabane, Linda

AU - Digilio, Giuseppe

AU - Aime, Silvio

PY - 2013/4/2

Y1 - 2013/4/2

N2 - Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

AB - Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

KW - MRI probe

KW - gadolinium

KW - liposome

KW - matrix metalloproteinases

KW - molecular imaging

UR - https://www.scopus.com/pages/publications/84875692900

U2 - 10.1002/anie.201209286

DO - 10.1002/anie.201209286

M3 - Article

SN - 1433-7851

VL - 52

SP - 3926

EP - 3930

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 14