A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging

Valeria Catanzaro; Concetta V. Gringeri; Valeria Menchise; Sergio Padovan; Cinzia Boffa; Walter Dastrù; Linda Chaabane; Giuseppe Digilio; Silvio Aime

doi:10.1002/anie.201209286

A R_2p/R_1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging

Valeria Catanzaro, Concetta V. Gringeri, Valeria Menchise, Sergio Padovan, Cinzia Boffa, Walter Dastrù, Linda Chaabane, Giuseppe Digilio, Silvio Aime

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R _2p/R_1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

Lingua originale	Inglese
pagine (da-a)	3926-3930
Numero di pagine	5
Rivista	Angewandte Chemie - International Edition
Volume	52
Numero di pubblicazione	14
DOI	https://doi.org/10.1002/anie.201209286
Stato di pubblicazione	Pubblicato - 2 apr 2013

Accesso al documento

10.1002/anie.201209286

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Cita questo

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title = "A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging",

abstract = "Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.",

keywords = "MRI probe, gadolinium, liposome, matrix metalloproteinases, molecular imaging",

author = "Valeria Catanzaro and Gringeri, {Concetta V.} and Valeria Menchise and Sergio Padovan and Cinzia Boffa and Walter Dastr{\`u} and Linda Chaabane and Giuseppe Digilio and Silvio Aime",

year = "2013",

month = apr,

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doi = "10.1002/anie.201209286",

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T1 - A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging

AU - Catanzaro, Valeria

AU - Gringeri, Concetta V.

AU - Menchise, Valeria

AU - Padovan, Sergio

AU - Boffa, Cinzia

AU - Dastrù, Walter

AU - Chaabane, Linda

AU - Digilio, Giuseppe

AU - Aime, Silvio

PY - 2013/4/2

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N2 - Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

AB - Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

KW - MRI probe

KW - gadolinium

KW - liposome

KW - matrix metalloproteinases

KW - molecular imaging

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DO - 10.1002/anie.201209286

M3 - Article

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 14