A Phthalocyanine with an Olefin at Its Center as Potential G‐Quadruplex Ligand

MANUEL PETROSELLI

doi:10.1002/slct.202202901

A Phthalocyanine with an Olefin at Its Center as Potential G‐Quadruplex Ligand

MANUEL PETROSELLI

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We report the synthesis of a polycyclic dicationic phthalocyanine through N-functionalization of the internal core with an olefin (C=C) and compared with its porphyrin analogues. Potential application of this new class of molecules as G-quadruplex (G4)-targeting ligand has been investigated by computational point of view, showing encouraging results with respect to the current benchmarks.

Lingua originale	Inglese
Rivista	ChemistrySelect
Volume	7
Numero di pubblicazione	43
DOI	https://doi.org/10.1002/slct.202202901
Stato di pubblicazione	Pubblicato - 2022

Keywords

Density Functional Calculations
Extended π-conjugation
G-Quadruplex-targeting ligands
Phthalocyanines
Polycyclic Hydrocarbons

Accesso al documento

10.1002/slct.202202901

https://hdl.handle.net/11579/208444

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abstract = "We report the synthesis of a polycyclic dicationic phthalocyanine through N-functionalization of the internal core with an olefin (C=C) and compared with its porphyrin analogues. Potential application of this new class of molecules as G-quadruplex (G4)-targeting ligand has been investigated by computational point of view, showing encouraging results with respect to the current benchmarks.",

keywords = "Density Functional Calculations, Extended π-conjugation, G-Quadruplex-targeting ligands, Phthalocyanines, Polycyclic Hydrocarbons, Density Functional Calculations, Extended π-conjugation, G-Quadruplex-targeting ligands, Phthalocyanines, Polycyclic Hydrocarbons",

author = "MANUEL PETROSELLI",

note = "Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",

year = "2022",

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AB - We report the synthesis of a polycyclic dicationic phthalocyanine through N-functionalization of the internal core with an olefin (C=C) and compared with its porphyrin analogues. Potential application of this new class of molecules as G-quadruplex (G4)-targeting ligand has been investigated by computational point of view, showing encouraging results with respect to the current benchmarks.

KW - Density Functional Calculations

KW - Extended π-conjugation

KW - G-Quadruplex-targeting ligands

KW - Phthalocyanines

KW - Polycyclic Hydrocarbons

KW - Density Functional Calculations

KW - Extended π-conjugation

KW - G-Quadruplex-targeting ligands

KW - Phthalocyanines

KW - Polycyclic Hydrocarbons

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DO - 10.1002/slct.202202901

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VL - 7

JO - ChemistrySelect

JF - ChemistrySelect

IS - 43

ER -

A Phthalocyanine with an Olefin at Its Center as Potential G‐Quadruplex Ligand

Abstract

Keywords

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