A Novel Short Convergent Entry into Himbacine Derivatives

Gunther Van Cauwenberge; Ling Jie Gao; Dirk Van Haver; Marco Milanesio; Davide Viterbo; Pierre J. De Clercq

doi:10.1021/ol025801g

A Novel Short Convergent Entry into Himbacine Derivatives

Gunther Van Cauwenberge
, Ling Jie Gao
, Dirk Van Haver
, Marco Milanesio
, Davide Viterbo
, Pierre J. De Clercq

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

(matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M₂ selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.

Lingua originale	Inglese
pagine (da-a)	1579-1582
Numero di pagine	4
Rivista	Organic Letters
Volume	4
Numero di pubblicazione	9
DOI	https://doi.org/10.1021/ol025801g
Stato di pubblicazione	Pubblicato - 2 mag 2002

Accesso al documento

10.1021/ol025801g

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{e0e00ed3b9fd42aba7d564adaa21b797,

title = "A Novel Short Convergent Entry into Himbacine Derivatives",

abstract = "(matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M2 selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.",

author = "\{Van Cauwenberge\}, Gunther and Gao, \{Ling Jie\} and \{Van Haver\}, Dirk and Marco Milanesio and Davide Viterbo and \{De Clercq\}, \{Pierre J.\}",

year = "2002",

month = may,

day = "2",

doi = "10.1021/ol025801g",

language = "English",

volume = "4",

pages = "1579--1582",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - A Novel Short Convergent Entry into Himbacine Derivatives

AU - Van Cauwenberge, Gunther

AU - Gao, Ling Jie

AU - Van Haver, Dirk

AU - Milanesio, Marco

AU - Viterbo, Davide

AU - De Clercq, Pierre J.

PY - 2002/5/2

Y1 - 2002/5/2

N2 - (matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M2 selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.

AB - (matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M2 selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.

UR - https://www.scopus.com/pages/publications/0037007744

U2 - 10.1021/ol025801g

DO - 10.1021/ol025801g

M3 - Article

SN - 1523-7060

VL - 4

SP - 1579

EP - 1582

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

A Novel Short Convergent Entry into Himbacine Derivatives

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo