A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

E GIANOLIO; Giovanni Battista GIOVENZANA; A CIAMPA; S LANZARDO; DANIELA IMPERIO; S. AIME

doi:10.1002/cmdc.200700182

A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

E GIANOLIO, Giovanni Battista GIOVENZANA, A CIAMPA, S LANZARDO, DANIELA IMPERIO, S. AIME

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5×106 particles. In this way only 15 % of the negative charges on the membrane has been used. The method has been validated by confocal microscopy.

Lingua originale	Inglese
pagine (da-a)	60-62
Numero di pagine	3
Rivista	ChemMedChem
Volume	3
Numero di pubblicazione	1
DOI	https://doi.org/10.1002/cmdc.200700182
Stato di pubblicazione	Pubblicato - 2008

Keywords

Gd chelates
cellular labeling
molecular imaging
nanostructures
polycations

Accesso al documento

10.1002/cmdc.200700182

http://hdl.handle.net/11579/28445

Altri file e collegamenti

handle

Cita questo

@article{dd887cc45e38432eb7ce0deb3d5f6e69,

title = "A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface",

abstract = "Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5×106 particles. In this way only 15 \% of the negative charges on the membrane has been used. The method has been validated by confocal microscopy.",

keywords = "Gd chelates, cellular labeling, molecular imaging, nanostructures, polycations, Gd chelates, cellular labeling, molecular imaging, nanostructures, polycations",

author = "E GIANOLIO and GIOVENZANA, \{Giovanni Battista\} and A CIAMPA and S LANZARDO and DANIELA IMPERIO and S. AIME",

year = "2008",

doi = "10.1002/cmdc.200700182",

language = "English",

volume = "3",

pages = "60--62",

journal = "ChemMedChem",

issn = "1860-7179",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

AU - GIANOLIO, E

AU - GIOVENZANA, Giovanni Battista

AU - CIAMPA, A

AU - LANZARDO, S

AU - IMPERIO, DANIELA

AU - AIME, S.

PY - 2008

Y1 - 2008

N2 - Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5×106 particles. In this way only 15 % of the negative charges on the membrane has been used. The method has been validated by confocal microscopy.

AB - Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5×106 particles. In this way only 15 % of the negative charges on the membrane has been used. The method has been validated by confocal microscopy.

KW - Gd chelates

KW - cellular labeling

KW - molecular imaging

KW - nanostructures

KW - polycations

KW - Gd chelates

KW - cellular labeling

KW - molecular imaging

KW - nanostructures

KW - polycations

UR - https://iris.uniupo.it/handle/11579/28445

U2 - 10.1002/cmdc.200700182

DO - 10.1002/cmdc.200700182

M3 - Article

SN - 1860-7179

VL - 3

SP - 60

EP - 62

JO - ChemMedChem

JF - ChemMedChem

IS - 1

ER -

A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

Abstract

Keywords

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo