A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

E GIANOLIO; Giovanni Battista GIOVENZANA; A CIAMPA; S LANZARDO; DANIELA IMPERIO; S. AIME

doi:10.1002/cmdc.200700182

A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

E GIANOLIO, Giovanni Battista GIOVENZANA, A CIAMPA, S LANZARDO, DANIELA IMPERIO, S. AIME

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5×106 particles. In this way only 15 % of the negative charges on the membrane has been used. The method has been validated by confocal microscopy.

Lingua originale	Inglese
pagine (da-a)	60-62
Numero di pagine	3
Rivista	ChemMedChem
Volume	3
Numero di pubblicazione	1
DOI	https://doi.org/10.1002/cmdc.200700182
Stato di pubblicazione	Pubblicato - 2008

Keywords

Gd chelates
cellular labeling
molecular imaging
nanostructures
polycations

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10.1002/cmdc.200700182

http://hdl.handle.net/11579/28445

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abstract = "Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5×106 particles. In this way only 15 % of the negative charges on the membrane has been used. The method has been validated by confocal microscopy.",

keywords = "Gd chelates, cellular labeling, molecular imaging, nanostructures, polycations, Gd chelates, cellular labeling, molecular imaging, nanostructures, polycations",

author = "E GIANOLIO and GIOVENZANA, {Giovanni Battista} and A CIAMPA and S LANZARDO and DANIELA IMPERIO and S. AIME",

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AU - LANZARDO, S

AU - IMPERIO, DANIELA

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KW - molecular imaging

KW - nanostructures

KW - polycations

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A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface

Abstract

Keywords

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