A novel luminescent bifunctional POSS as a molecular platform for biomedical applications

Francesco Olivero, Filippo Renò, Fabio Carniato, Manuela Rizzi, Mario Cannas, Leonardo Marchese

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A novel luminescent polyhedral oligomeric silsesquioxane (POSS) containing in the structure a fluorescein derivative molecule and a carboxylic functionality, suitable to anchor different organic compounds (dyes, markers, drugs, contrast agents,...), was successfully synthesized and characterized in this manuscript by a multidisciplinary approach. An emission enhancement of the dye of ca. four times was found after reaction with POSS, rendering this new hybrid compound a promising contrast agent for optical imaging. In vitro tests on tumoral HeLa cells demonstrated that the luminescent POSS (namely POSS-F), here described, is able to be taken up in the cell cytosol by an efficient and selective process. Its high chemical versatility and peculiar properties could render this novel bifunctional POSS a molecular platform for biomedical applications.

Lingua originaleInglese
pagine (da-a)7467-7473
Numero di pagine7
RivistaDalton Transactions
Volume41
Numero di pubblicazione25
DOI
Stato di pubblicazionePubblicato - 7 lug 2012

Fingerprint

Entra nei temi di ricerca di 'A novel luminescent bifunctional POSS as a molecular platform for biomedical applications'. Insieme formano una fingerprint unica.

Cita questo