A Novel Class of 1H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by 14N-Containing Imidazole Moieties

Simona Baroni, Rachele Stefania, Lionel M. Broche, Nicholas Senn, David J. Lurie, P. James Ross, Silvio Aime, Simonetta Geninatti Crich

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

This study reports the development of a completely new class of MRI contrast agents, displaying remarkable relaxation effects in the absence of paramagnetic metal ions. Their detection requires the acquisition of images at variable magnetic field strength as provided by fast field cycling imaging scanners. They contain poly-histidine chains (poly-His), whose imidazole groups generate 14N-quadrupolar-peaks that cause a relaxation enhancement of water protons at a frequency (1.38±0.3 MHz) that is readily detectable from the frequencies associated with endogenous proteins. The poly-His quadrupolar peaks are detectable only when the polymer is in a solid-like form, that is, at pH>6.6. Above this value, their intensity is pH dependent and can be used to report on the occurring pH changes. On this basis, the poly-His moieties were conjugated to biocompatible polymers, such as polylactic and glycolic acid, in order to form stable nanoparticles able to encapsulate structured water in their core. FFC images were acquired to assess their contrast-generating ability.

Lingua originaleInglese
pagine (da-a)4208-4214
Numero di pagine7
RivistaAngewandte Chemie - International Edition
Volume60
Numero di pubblicazione8
DOI
Stato di pubblicazionePubblicato - 19 feb 2021
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'A Novel Class of 1H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by 14N-Containing Imidazole Moieties'. Insieme formano una fingerprint unica.

Cita questo