A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers.

L Magrassi; GIULIA PINTON; S Luzzi; S Comincini; A Scravaglieri; V Gigliotti; Bernardoni BL; I D'Agostino; F Juretich; Motta C La; Silvia GARAVAGLIA

doi:10.3390/cancers16132397

A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers.

L Magrassi, GIULIA PINTON, S Luzzi, S Comincini, A Scravaglieri, V Gigliotti, Bernardoni BL, I D'Agostino, F Juretich, Motta C La, Silvia GARAVAGLIA

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Aldehyde dehydrogenases of the subfamily 1A (ALDH1A) are enzymes involved in the synthesis of retinoic acid, which is necessary for the normal development and maintenance of epithelia, reproduction, memory, and immune function in adults. ALDH1A3, one of the enzymes that belong to the ALD1A subfamily, is also expressed at high levels in many human cancers like glioblastoma and mesothelioma. Herein, we review the role of ALDH1A3 in cancer, showing its relation with excessive proliferation, chemoresistance, and invasiveness. We also illustrate the current attempts to develop ALDH1A3-selective inhibitors and specific fluorescent probes that are potentially useful for cancer therapy and fluorescence-guided tumor resection.

Lingua originale	Inglese
Rivista	Cancers
DOI	https://doi.org/10.3390/cancers16132397
Stato di pubblicazione	Pubblicato - 2024

Keywords

ALDH1A3
aldehyde dehydrogenase
cancers
fluorescence-guided surgery
glioblastoma
mesothelioma
retinoic acid

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10.3390/cancers16132397

https://hdl.handle.net/11579/195302

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Magrassi, L., PINTON, GIULIA., Luzzi, S., Comincini, S., Scravaglieri, A., Gigliotti, V., BL, B., D'Agostino, I., Juretich, F., La, M. C., & GARAVAGLIA, S. (2024). A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers. Cancers. https://doi.org/10.3390/cancers16132397

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title = "A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers.",

abstract = "Aldehyde dehydrogenases of the subfamily 1A (ALDH1A) are enzymes involved in the synthesis of retinoic acid, which is necessary for the normal development and maintenance of epithelia, reproduction, memory, and immune function in adults. ALDH1A3, one of the enzymes that belong to the ALD1A subfamily, is also expressed at high levels in many human cancers like glioblastoma and mesothelioma. Herein, we review the role of ALDH1A3 in cancer, showing its relation with excessive proliferation, chemoresistance, and invasiveness. We also illustrate the current attempts to develop ALDH1A3-selective inhibitors and specific fluorescent probes that are potentially useful for cancer therapy and fluorescence-guided tumor resection.",

keywords = "ALDH1A3, aldehyde dehydrogenase, cancers, fluorescence-guided surgery, glioblastoma, mesothelioma, retinoic acid, ALDH1A3, aldehyde dehydrogenase, cancers, fluorescence-guided surgery, glioblastoma, mesothelioma, retinoic acid",

author = "L Magrassi and GIULIA PINTON and S Luzzi and S Comincini and A Scravaglieri and V Gigliotti and Bernardoni BL and I D'Agostino and F Juretich and La, {Motta C} and Silvia GARAVAGLIA",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

doi = "10.3390/cancers16132397",

language = "English",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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Magrassi, L, PINTON, GIULIA, Luzzi, S, Comincini, S, Scravaglieri, A, Gigliotti, V, BL, B, D'Agostino, I, Juretich, F, La, MC & GARAVAGLIA, S 2024, 'A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers.', Cancers. https://doi.org/10.3390/cancers16132397

TY - JOUR

T1 - A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers.

AU - Magrassi, L

AU - PINTON, GIULIA

AU - Luzzi, S

AU - Comincini, S

AU - Scravaglieri, A

AU - Gigliotti, V

AU - BL, Bernardoni

AU - D'Agostino, I

AU - Juretich, F

AU - La, Motta C

AU - GARAVAGLIA, Silvia

PY - 2024

Y1 - 2024

N2 - Aldehyde dehydrogenases of the subfamily 1A (ALDH1A) are enzymes involved in the synthesis of retinoic acid, which is necessary for the normal development and maintenance of epithelia, reproduction, memory, and immune function in adults. ALDH1A3, one of the enzymes that belong to the ALD1A subfamily, is also expressed at high levels in many human cancers like glioblastoma and mesothelioma. Herein, we review the role of ALDH1A3 in cancer, showing its relation with excessive proliferation, chemoresistance, and invasiveness. We also illustrate the current attempts to develop ALDH1A3-selective inhibitors and specific fluorescent probes that are potentially useful for cancer therapy and fluorescence-guided tumor resection.

AB - Aldehyde dehydrogenases of the subfamily 1A (ALDH1A) are enzymes involved in the synthesis of retinoic acid, which is necessary for the normal development and maintenance of epithelia, reproduction, memory, and immune function in adults. ALDH1A3, one of the enzymes that belong to the ALD1A subfamily, is also expressed at high levels in many human cancers like glioblastoma and mesothelioma. Herein, we review the role of ALDH1A3 in cancer, showing its relation with excessive proliferation, chemoresistance, and invasiveness. We also illustrate the current attempts to develop ALDH1A3-selective inhibitors and specific fluorescent probes that are potentially useful for cancer therapy and fluorescence-guided tumor resection.

KW - ALDH1A3

KW - aldehyde dehydrogenase

KW - cancers

KW - fluorescence-guided surgery

KW - glioblastoma

KW - mesothelioma

KW - retinoic acid

KW - ALDH1A3

KW - aldehyde dehydrogenase

KW - cancers

KW - fluorescence-guided surgery

KW - glioblastoma

KW - mesothelioma

KW - retinoic acid

UR - https://iris.uniupo.it/handle/11579/195302

U2 - 10.3390/cancers16132397

DO - 10.3390/cancers16132397

M3 - Article

SN - 2072-6694

JO - Cancers

JF - Cancers

ER -

A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers.

Abstract

Keywords

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