A new furoxan NO-donor rabeprazole derivative and related compounds

Giovanni SORBA; Ubaldina GALLI; C. CENA; R. FRUTTERO; A. GASCO; G. MORINI; M. ADAMI; G. CORUZZI; M. I. BRENCIAGLIA; F. DUBINI

A new furoxan NO-donor rabeprazole derivative and related compounds

Giovanni SORBA, Ubaldina GALLI, C. CENA, R. FRUTTERO, A. GASCO, G. MORINI, M. ADAMI, G. CORUZZI, M. I. BRENCIAGLIA, F. DUBINI

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

Lingua originale	Inglese
pagine (da-a)	899-903
Numero di pagine	5
Rivista	ChemBioChem
Volume	4
Stato di pubblicazione	Pubblicato - 2003

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http://hdl.handle.net/11579/30408

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abstract = "Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.",

author = "Giovanni SORBA and Ubaldina GALLI and C. CENA and R. FRUTTERO and A. GASCO and G. MORINI and M. ADAMI and G. CORUZZI and BRENCIAGLIA, \{M. I.\} and F. DUBINI",

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T1 - A new furoxan NO-donor rabeprazole derivative and related compounds

AU - SORBA, Giovanni

AU - GALLI, Ubaldina

AU - CENA, C.

AU - FRUTTERO, R.

AU - GASCO, A.

AU - MORINI, G.

AU - ADAMI, M.

AU - CORUZZI, G.

AU - BRENCIAGLIA, M. I.

AU - DUBINI, F.

PY - 2003

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N2 - Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

AB - Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

UR - https://iris.uniupo.it/handle/11579/30408

M3 - Article

SN - 1439-4227

VL - 4

SP - 899

EP - 903

JO - ChemBioChem

JF - ChemBioChem

ER -

A new furoxan NO-donor rabeprazole derivative and related compounds

Abstract

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