A new furoxan NO-donor rabeprazole derivative and related compounds

Giovanni Sorba; Ubaldina Galli; Clara Cena; Roberta Fruttero; Alberto Gasco; Giuseppina Morini; Maristella Adami; Gabriella Coruzzi; Maria Immacolata Brenciaglia; Francesco Dubini

doi:10.1002/cbic.200300617

A new furoxan NO-donor rabeprazole derivative and related compounds

Giovanni Sorba, Ubaldina Galli, Clara Cena, Roberta Fruttero, Alberto Gasco, Giuseppina Morini, Maristella Adami, Gabriella Coruzzi, Maria Immacolata Brenciaglia, Francesco Dubini

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

Lingua originale	Inglese
pagine (da-a)	899-903
Numero di pagine	5
Rivista	ChemBioChem
Volume	4
Numero di pubblicazione	9
DOI	https://doi.org/10.1002/cbic.200300617
Stato di pubblicazione	Pubblicato - 5 set 2003

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10.1002/cbic.200300617

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title = "A new furoxan NO-donor rabeprazole derivative and related compounds",

abstract = "Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.",

keywords = "Drug design, Furoxans, Medicinal chemistry, Nitric oxide, Rabeprazole",

author = "Giovanni Sorba and Ubaldina Galli and Clara Cena and Roberta Fruttero and Alberto Gasco and Giuseppina Morini and Maristella Adami and Gabriella Coruzzi and Brenciaglia, {Maria Immacolata} and Francesco Dubini",

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AU - Sorba, Giovanni

AU - Galli, Ubaldina

AU - Cena, Clara

AU - Fruttero, Roberta

AU - Gasco, Alberto

AU - Morini, Giuseppina

AU - Adami, Maristella

AU - Coruzzi, Gabriella

AU - Brenciaglia, Maria Immacolata

AU - Dubini, Francesco

PY - 2003/9/5

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N2 - Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

AB - Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

KW - Drug design

KW - Furoxans

KW - Medicinal chemistry

KW - Nitric oxide

KW - Rabeprazole

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JO - ChemBioChem

JF - ChemBioChem

IS - 9

ER -

A new furoxan NO-donor rabeprazole derivative and related compounds

Abstract

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