Abstract
Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (kex) by nearly two orders of magnitude; the 1H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems.
Lingua originale | Inglese |
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pagine (da-a) | 9712-9714 |
Numero di pagine | 3 |
Rivista | Dalton Transactions |
Numero di pubblicazione | 44 |
DOI | |
Stato di pubblicazione | Pubblicato - 2009 |