A Neutral and Stable Macrocyclic Mn(II) Complex for MRI Tumor Visualization

L. Leone, A. Anemone, A. Carella, E. Botto, D. L. Longo, LORENZO TEI

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A stable and inert amphiphilic Mn(II) complex based on a bisamide derivative of 1,4-DO2A (DO2A=tetraazacyclododecane-1,4-diacetic acid) was synthesized and its H-1 NMR relaxometric behavior was investigated as a function of the magnetic field strength, pH and temperature. The interaction with human serum albumin (HSA) was also studied via relaxometry showing a good relaxivity enhancement at low field (at 1T and 298 K the relaxivity increases from 4.5 mM(-1) s(-1) of the Mn(II)-complex to 14.0 mM(-1) s(-1) of the complex-HSA supramolecular adduct). In vivo biodistribution and MRI studies highlighted a rapid and mixed renal/liver elimination without spleen accumulation from healthy mice and good contrast enhancing properties in a breast tumor murine model. A comparison with a clinically approved Gd(III) agent (GdBOPTA, Multihance (R)) underlined that the proposed Mn(II) contrast agent gave comparable tumor contrast enhancement up to 3 hours post-injection.
Lingua originaleInglese
RivistaChemMedChem
Volume17
Numero di pubblicazione24
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • MRI
  • Manganese
  • contrast agent
  • relaxometry
  • tumor

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