TY - JOUR
T1 - A multi-omics approach to investigate the inflammatory response to life course socioeconomic position
AU - Castagné, Raphaële
AU - Kelly-Irving, Michelle
AU - Krogh, Vittorio
AU - Palli, Domenico
AU - Panico, Salvatore
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Hebels, Dennie G.A.J.
AU - Kleinjans, Jos C.S.
AU - De Kok, Theo M.C.M.
AU - Georgiadis, Panagiotis
AU - Kyrtopoulos, Soterios A.
AU - Vermeulen, Roel
AU - Stringhini, Silvia
AU - Vineis, Paolo
AU - Chadeau-Hyam, Marc
AU - Delpierre, Cyrille
N1 - Publisher Copyright:
© 2020 Future Medicine Ltd.. All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
AB - Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
KW - DNA methylation
KW - gene expression
KW - inflammation
KW - life course epidemiology
KW - protein
KW - socioeconomic position
UR - https://www.scopus.com/pages/publications/85090903295
U2 - 10.2217/epi-2019-0261
DO - 10.2217/epi-2019-0261
M3 - Article
SN - 1750-1911
VL - 12
SP - 1287
EP - 1302
JO - Epigenomics
JF - Epigenomics
IS - 15
ER -
