A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

R. Castagne; M. Kelly-Irving; V. Krogh; D. Palli; S. Panico; Carlotta SACERDOTE; R. Tumino; D. G. A. J. Hebels; J. C. S. Kleinjans; Kok T. M. C. M. De; P. Georgiadis; S. A. Kyrtopoulos; R. Vermeulen; S. Stringhini; P. Vineis; M. Chadeau-Hyam; C. Delpierre

doi:10.2217/epi-2019-0261

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

R. Castagne, M. Kelly-Irving, V. Krogh, D. Palli, S. Panico, Carlotta SACERDOTE, R. Tumino, D. G. A. J. Hebels, J. C. S. Kleinjans, Kok T. M. C. M. De, P. Georgiadis, S. A. Kyrtopoulos, R. Vermeulen, S. Stringhini, P. Vineis, M. Chadeau-Hyam, C. Delpierre

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

Lingua originale	Inglese
pagine (da-a)	1287-1302
Numero di pagine	16
Rivista	Epigenomics
Volume	12
Numero di pubblicazione	15
DOI	https://doi.org/10.2217/epi-2019-0261
Stato di pubblicazione	Pubblicato - 2020

Keywords

DNA methylation
gene expression
inflammation
life course epidemiology
protein
socioeconomic position

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Accesso al documento

10.2217/epi-2019-0261

https://hdl.handle.net/11579/199642

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Castagne, R., Kelly-Irving, M., Krogh, V., Palli, D., Panico, S., SACERDOTE, C., Tumino, R., Hebels, D. G. A. J., Kleinjans, J. C. S., De, K. T. M. C. M., Georgiadis, P., Kyrtopoulos, S. A., Vermeulen, R., Stringhini, S., Vineis, P., Chadeau-Hyam, M., & Delpierre, C. (2020). A multi-omics approach to investigate the inflammatory response to life course socioeconomic position. Epigenomics, 12(15), 1287-1302. https://doi.org/10.2217/epi-2019-0261

@article{d201070456bf49869ee4056149e1805a,

title = "A multi-omics approach to investigate the inflammatory response to life course socioeconomic position",

abstract = "Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.",

keywords = "DNA methylation, gene expression, inflammation, life course epidemiology, protein, socioeconomic position, DNA methylation, gene expression, inflammation, life course epidemiology, protein, socioeconomic position",

author = "R. Castagne and M. Kelly-Irving and V. Krogh and D. Palli and S. Panico and Carlotta SACERDOTE and R. Tumino and Hebels, {D. G. A. J.} and Kleinjans, {J. C. S.} and De, {Kok T. M. C. M.} and P. Georgiadis and Kyrtopoulos, {S. A.} and R. Vermeulen and S. Stringhini and P. Vineis and M. Chadeau-Hyam and C. Delpierre",

year = "2020",

doi = "10.2217/epi-2019-0261",

language = "English",

volume = "12",

pages = "1287--1302",

journal = "Epigenomics",

issn = "1750-1911",

publisher = "Taylor and Francis Ltd.",

number = "15",

}

Castagne, R, Kelly-Irving, M, Krogh, V, Palli, D, Panico, S, SACERDOTE, C, Tumino, R, Hebels, DGAJ, Kleinjans, JCS, De, KTMCM, Georgiadis, P, Kyrtopoulos, SA, Vermeulen, R, Stringhini, S, Vineis, P, Chadeau-Hyam, M & Delpierre, C 2020, 'A multi-omics approach to investigate the inflammatory response to life course socioeconomic position', Epigenomics, vol. 12, n. 15, pagg. 1287-1302. https://doi.org/10.2217/epi-2019-0261

TY - JOUR

T1 - A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

AU - Castagne, R.

AU - Kelly-Irving, M.

AU - Krogh, V.

AU - Palli, D.

AU - Panico, S.

AU - SACERDOTE, Carlotta

AU - Tumino, R.

AU - Hebels, D. G. A. J.

AU - Kleinjans, J. C. S.

AU - De, Kok T. M. C. M.

AU - Georgiadis, P.

AU - Kyrtopoulos, S. A.

AU - Vermeulen, R.

AU - Stringhini, S.

AU - Vineis, P.

AU - Chadeau-Hyam, M.

AU - Delpierre, C.

PY - 2020

Y1 - 2020

N2 - Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

AB - Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

KW - DNA methylation

KW - gene expression

KW - inflammation

KW - life course epidemiology

KW - protein

KW - socioeconomic position

KW - DNA methylation

KW - gene expression

KW - inflammation

KW - life course epidemiology

KW - protein

KW - socioeconomic position

UR - https://iris.uniupo.it/handle/11579/199642

U2 - 10.2217/epi-2019-0261

DO - 10.2217/epi-2019-0261

M3 - Article

SN - 1750-1911

VL - 12

SP - 1287

EP - 1302

JO - Epigenomics

JF - Epigenomics

IS - 15

ER -

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

Abstract

Keywords

OSS delle Nazioni Unite

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