A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase

G. C. Endemann; A. Graziani; L. C. Cantley

doi:10.1042/bj2730063

A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase

G. C. Endemann, A. Graziani, L. C. Cantley

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the type II PtdIns 4-kinase.

Lingua originale	Inglese
pagine (da-a)	63-66
Numero di pagine	4
Rivista	Biochemical Journal
Volume	273
Numero di pubblicazione	1
DOI	https://doi.org/10.1042/bj2730063
Stato di pubblicazione	Pubblicato - 1991
Pubblicato esternamente	Sì

Accesso al documento

10.1042/bj2730063

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{b61f56a6030f4b55aecbe98bb746dad7,

title = "A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase",

abstract = "A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the type II PtdIns 4-kinase.",

author = "Endemann, {G. C.} and A. Graziani and Cantley, {L. C.}",

year = "1991",

doi = "10.1042/bj2730063",

language = "English",

volume = "273",

pages = "63--66",

journal = "Biochemical Journal",

issn = "0264-6021",

publisher = "Portland Press Ltd",

number = "1",

}

TY - JOUR

T1 - A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase

AU - Endemann, G. C.

AU - Graziani, A.

AU - Cantley, L. C.

PY - 1991

Y1 - 1991

N2 - A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the type II PtdIns 4-kinase.

AB - A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the type II PtdIns 4-kinase.

UR - http://www.scopus.com/inward/record.url?scp=0026070950&partnerID=8YFLogxK

U2 - 10.1042/bj2730063

DO - 10.1042/bj2730063

M3 - Article

SN - 0264-6021

VL - 273

SP - 63

EP - 66

JO - Biochemical Journal

JF - Biochemical Journal

IS - 1

ER -

A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo