A micellar-hydrogel nanogrid from a UV crosslinked inulin derivative for the simultaneous delivery of hydrophobic and hydrophilic drugs

Delia Mandracchia, Adriana Trapani, Sara Perteghella, Cinzia Di Franco, Maria Luisa Torre, Enrica Calleri, Giuseppe Tripodo

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present.

Lingua originaleInglese
Numero di articolo97
RivistaPharmaceutics
Volume10
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - set 2018
Pubblicato esternamente

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