A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications

Silvio Aime; Mauro Botta; Simonetta Geninatti Crich; Giovanni Giovenzana; Giovanni Palmisano; Massimo Sisti

doi:10.1039/a900499h

A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications

Silvio Aime, Mauro Botta, Simonetta Geninatti Crich, Giovanni Giovenzana, Giovanni Palmisano, Massimo Sisti

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The ability of the paramagnetic macromolecular complex (GdDO3ASQ)₃₀-Orn₁₁₄ to enhance the water proton relaxation rate has been found to be a function of pH; this behaviour is related to the structural changes occurring in the polypeptide upon protonation of the side-chain NH₂ groups.

Lingua originale	Inglese
pagine (da-a)	1577-1578
Numero di pagine	2
Rivista	Chemical Communications
Numero di pubblicazione	16
DOI	https://doi.org/10.1039/a900499h
Stato di pubblicazione	Pubblicato - 21 ago 1999

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10.1039/a900499h

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title = "A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications",

abstract = "The ability of the paramagnetic macromolecular complex (GdDO3ASQ)30-Orn114 to enhance the water proton relaxation rate has been found to be a function of pH; this behaviour is related to the structural changes occurring in the polypeptide upon protonation of the side-chain NH2 groups.",

author = "Silvio Aime and Mauro Botta and Crich, {Simonetta Geninatti} and Giovanni Giovenzana and Giovanni Palmisano and Massimo Sisti",

year = "1999",

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AU - Aime, Silvio

AU - Botta, Mauro

AU - Crich, Simonetta Geninatti

AU - Giovenzana, Giovanni

AU - Palmisano, Giovanni

AU - Sisti, Massimo

PY - 1999/8/21

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AB - The ability of the paramagnetic macromolecular complex (GdDO3ASQ)30-Orn114 to enhance the water proton relaxation rate has been found to be a function of pH; this behaviour is related to the structural changes occurring in the polypeptide upon protonation of the side-chain NH2 groups.

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DO - 10.1039/a900499h

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JO - Chemical Communications

JF - Chemical Communications

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A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications

Abstract

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