TY - JOUR
T1 - A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers
AU - Castagné, Raphaële
AU - Delpierre, Cyrille
AU - Kelly-Irving, Michelle
AU - Campanella, Gianluca
AU - Guida, Florence
AU - Krogh, Vittorio
AU - Palli, Domenico
AU - Panico, Salvatore
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Kyrtopoulos, Soterios
AU - Hosnijeh, Fatemeh Saberi
AU - Lang, Thierry
AU - Vermeulen, Roel
AU - Vineis, Paolo
AU - Stringhini, Silvia
AU - Chadeau-Hyam, Marc
PY - 2016/4/27
Y1 - 2016/4/27
N2 - Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; β = 0.29; P = 0.002), and an increased inflammatory score (β = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father's occupation and the highest household occupation, revealing a significant difference between "stable Non-manual" profiles over the life course versus "Manual to Nonmanual" profiles (β = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course.
AB - Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; β = 0.29; P = 0.002), and an increased inflammatory score (β = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father's occupation and the highest household occupation, revealing a significant difference between "stable Non-manual" profiles over the life course versus "Manual to Nonmanual" profiles (β = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course.
UR - http://www.scopus.com/inward/record.url?scp=84964621908&partnerID=8YFLogxK
U2 - 10.1038/srep25170
DO - 10.1038/srep25170
M3 - Article
SN - 2045-2322
VL - 6
JO - Scientific Reports
JF - Scientific Reports
M1 - 25170
ER -
