Abstract
A one-pot, high-yield procedure for synthesizing lanthionine-containing peptides was developed. It relies on the S-alkylation of cysteine-containing peptides with chiral cyclic sulfamidates. The key feature of this approach is the use of mild reaction conditions (only activated molecular sieves are employed as the catalyst), leading to good chemoselectivity and excellent stereochemical control. The potential of the new methodology has been investigated by synthesizing the thioether ring of a natural lantibiotic, Haloduracin β.
Lingua originale | Inglese |
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pagine (da-a) | 7478-7482 |
Numero di pagine | 5 |
Rivista | Organic Letters |
Volume | 20 |
Numero di pubblicazione | 23 |
DOI | |
Stato di pubblicazione | Pubblicato - 7 dic 2018 |