A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

RA Scott; DF Freitag; L Li; AY Chu; P Surendran; R Young; N Grarup; A Stancáková; Y Chen; TV Varga; H Yaghootkar; J Luan; JH Zhao; SM Willems; J Wessel; S Wang; N Maruthur; K Michailidou; A Pirie; der Lee SJ van; C Gillson; Olama AA Al; P Amouyel; L Arriola; D Arveiler; I Aviles-Olmos; B Balkau; A Barricarte; I Barroso; SB Garcia; JC Bis; S Blankenberg; M Boehnke; H Boeing; E Boerwinkle; IB Borecki; J Bork-Jensen; S Bowden; C Caldas; M Caslake; CVD50 consortium; LA Cupples; C Cruchaga; J Czajkowski; Hoed M den; JA Dunn; HM Earl; GB Ehret; E Ferrannini; J Ferrieres; T Foltynie; I Ford; NG Forouhi; F Gianfagna; C Gonzalez; S Grioni; L Hiller; JH Jansson; ME Jørgensen; JW Jukema; R Kaaks; F Kee; ND Kerrison; TJ Key; J Kontto; Z Kote-Jarai; AT Kraja; K Kuulasmaa; J Kuusisto; A Linneberg; C Liu; G Marenne; KL Mohlke; AP Morris; K Muir; M Müller-Nurasyid; PB Munroe; C Navarro; SF Nielsen; PM Nilsson; BG Nordestgaard; CJ Packard; D Palli; S Panico; GM Peloso; M Perola; A Peters; CJ Poole; JR Quirós; O Rolandsson; Carlotta SACERDOTE; V Salomaa; MJ Sánchez; N Sattar; SJ Sharp; R Sims; N Slimani; JA Smith; DJ Thompson; S Trompet; R Tumino; der A DL van; der Schouw YT van; J Virtamo; M Walker; K Walter; GERAD_EC Consortium; Neurology Working Group of the Cohorts for Heart; Research in Genomic Epidemiology (CHARGE) Aging; Alzheimer’s Disease Genetics Consortium; Pancreatic Cancer Cohort Consortium; Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) European; null EPIC-InterAct; JE Abraham; LT Amundadottir; JL Aponte; AS Butterworth; J Dupuis; DF Easton; RA Eeles; J Erdmann; PW Franks; TM Frayling; T Hansen; JM Howson; T Jørgensen; J Kooner; M Laakso; C Langenberg; MI McCarthy; JS Pankow; O Pedersen; E Riboli; JI Rotter; D Saleheen; NJ Samani; H Schunkert; P Vollenweider; S O'Rahilly; CHARGE consortium; CHD Exome+ Consortium; CARDIOGRAM Exome Consortium; P Deloukas; J Danesh; MO Goodarzi; S Kathiresan; JB Meigs; MG Ehm; NJ Wareham; DM. Waterworth

doi:10.1126/scitranslmed.aad3744

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

RA Scott, DF Freitag, L Li, AY Chu, P Surendran, R Young, N Grarup, A Stancáková, Y Chen, TV Varga, H Yaghootkar, J Luan, JH Zhao, SM Willems, J Wessel, S Wang, N Maruthur, K Michailidou, A Pirie, der Lee SJ vanC Gillson, Olama AA Al, P Amouyel, L Arriola, D Arveiler, I Aviles-Olmos, B Balkau, A Barricarte, I Barroso, SB Garcia, JC Bis, S Blankenberg, M Boehnke, H Boeing, E Boerwinkle, IB Borecki, J Bork-Jensen, S Bowden, C Caldas, M Caslake, CVD50 consortium, LA Cupples, C Cruchaga, J Czajkowski, Hoed M den, JA Dunn, HM Earl, GB Ehret, E Ferrannini, J Ferrieres, T Foltynie, I Ford, NG Forouhi, F Gianfagna, C Gonzalez, S Grioni, L Hiller, JH Jansson, ME Jørgensen, JW Jukema, R Kaaks, F Kee, ND Kerrison, TJ Key, J Kontto, Z Kote-Jarai, AT Kraja, K Kuulasmaa, J Kuusisto, A Linneberg, C Liu, G Marenne, KL Mohlke, AP Morris, K Muir, M Müller-Nurasyid, PB Munroe, C Navarro, SF Nielsen, PM Nilsson, BG Nordestgaard, CJ Packard, D Palli, S Panico, GM Peloso, M Perola, A Peters, CJ Poole, JR Quirós, O Rolandsson, Carlotta SACERDOTE, V Salomaa, MJ Sánchez, N Sattar, SJ Sharp, R Sims, N Slimani, JA Smith, DJ Thompson, S Trompet, R Tumino, der A DL van, der Schouw YT van, J Virtamo, M Walker, K Walter, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart, Research in Genomic Epidemiology (CHARGE) Aging, Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) European, EPIC-InterAct, JE Abraham, LT Amundadottir, JL Aponte, AS Butterworth, J Dupuis, DF Easton, RA Eeles, J Erdmann, PW Franks, TM Frayling, T Hansen, JM Howson, T Jørgensen, J Kooner, M Laakso, C Langenberg, MI McCarthy, JS Pankow, O Pedersen, E Riboli, JI Rotter, D Saleheen, NJ Samani, H Schunkert, P Vollenweider, S O'Rahilly, CHARGE consortium, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, P Deloukas, J Danesh, MO Goodarzi, S Kathiresan, JB Meigs, MG Ehm, NJ Wareham, DM. Waterworth

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista

Lingua originale	Inglese
Rivista	Science Translational Medicine
Volume	8
Numero di pubblicazione	341
DOI	https://doi.org/10.1126/scitranslmed.aad3744
Stato di pubblicazione	Pubblicato - 2016

Accesso al documento

10.1126/scitranslmed.aad3744

https://hdl.handle.net/11579/176959

Altri file e collegamenti

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Cita questo

Scott, RA., Freitag, DF., Li, L., Chu, AY., Surendran, P., Young, R., Grarup, N., Stancáková, A., Chen, Y., Varga, TV., Yaghootkar, H., Luan, J., Zhao, JH., Willems, SM., Wessel, J., Wang, S., Maruthur, N., Michailidou, K., Pirie, A., ... Waterworth, DM. (2016). A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Science Translational Medicine, 8(341). https://doi.org/10.1126/scitranslmed.aad3744

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title = "A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease",

author = "RA Scott and DF Freitag and L Li and AY Chu and P Surendran and R Young and N Grarup and A Stanc{\'a}kov{\'a} and Y Chen and TV Varga and H Yaghootkar and J Luan and JH Zhao and SM Willems and J Wessel and S Wang and N Maruthur and K Michailidou and A Pirie and van, {der Lee SJ} and C Gillson and Al, {Olama AA} and P Amouyel and L Arriola and D Arveiler and I Aviles-Olmos and B Balkau and A Barricarte and I Barroso and SB Garcia and JC Bis and S Blankenberg and M Boehnke and H Boeing and E Boerwinkle and IB Borecki and J Bork-Jensen and S Bowden and C Caldas and M Caslake and CVD50 consortium and LA Cupples and C Cruchaga and J Czajkowski and den, {Hoed M} and JA Dunn and HM Earl and GB Ehret and E Ferrannini and J Ferrieres and T Foltynie and I Ford and NG Forouhi and F Gianfagna and C Gonzalez and S Grioni and L Hiller and JH Jansson and ME J{\o}rgensen and JW Jukema and R Kaaks and F Kee and ND Kerrison and TJ Key and J Kontto and Z Kote-Jarai and AT Kraja and K Kuulasmaa and J Kuusisto and A Linneberg and C Liu and G Marenne and KL Mohlke and AP Morris and K Muir and M M{\"u}ller-Nurasyid and PB Munroe and C Navarro and SF Nielsen and PM Nilsson and BG Nordestgaard and CJ Packard and D Palli and S Panico and GM Peloso and M Perola and A Peters and CJ Poole and JR Quir{\'o}s and O Rolandsson and Carlotta SACERDOTE and V Salomaa and MJ S{\'a}nchez and N Sattar and SJ Sharp and R Sims and N Slimani and JA Smith and DJ Thompson and S Trompet and R Tumino and van, {der A DL} and van, {der Schouw YT} and J Virtamo and M Walker and K Walter and GERAD_EC Consortium and Heart, {Neurology Working Group of the Cohorts for} and Aging, {Research in Genomic Epidemiology (CHARGE)} and Consortium, {Alzheimer{\textquoteright}s Disease Genetics} and Consortium, {Pancreatic Cancer Cohort} and European, {Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD)} and EPIC-InterAct and JE Abraham and LT Amundadottir and JL Aponte and AS Butterworth and J Dupuis and DF Easton and RA Eeles and J Erdmann and PW Franks and TM Frayling and T Hansen and JM Howson and T J{\o}rgensen and J Kooner and M Laakso and C Langenberg and MI McCarthy and JS Pankow and O Pedersen and E Riboli and JI Rotter and D Saleheen and NJ Samani and H Schunkert and P Vollenweider and S O'Rahilly and CHARGE consortium and Consortium, {CHD Exome+} and Consortium, {CARDIOGRAM Exome} and P Deloukas and J Danesh and MO Goodarzi and S Kathiresan and JB Meigs and MG Ehm and NJ Wareham and DM. Waterworth",

year = "2016",

doi = "10.1126/scitranslmed.aad3744",

language = "English",

volume = "8",

journal = "Science Translational Medicine",

issn = "1946-6242",

publisher = "American Association for the Advancement of Science",

number = "341",

}

Scott, RA, Freitag, DF, Li, L, Chu, AY, Surendran, P, Young, R, Grarup, N, Stancáková, A, Chen, Y, Varga, TV, Yaghootkar, H, Luan, J, Zhao, JH, Willems, SM, Wessel, J, Wang, S, Maruthur, N, Michailidou, K, Pirie, A, van, DLSJ, Gillson, C, Al, OAA, Amouyel, P, Arriola, L, Arveiler, D, Aviles-Olmos, I, Balkau, B, Barricarte, A, Barroso, I, Garcia, SB, Bis, JC, Blankenberg, S, Boehnke, M, Boeing, H, Boerwinkle, E, Borecki, IB, Bork-Jensen, J, Bowden, S, Caldas, C, Caslake, M, consortium, CVD, Cupples, LA, Cruchaga, C, Czajkowski, J, den, HM, Dunn, JA, Earl, HM, Ehret, GB, Ferrannini, E, Ferrieres, J, Foltynie, T, Ford, I, Forouhi, NG, Gianfagna, F, Gonzalez, C, Grioni, S, Hiller, L, Jansson, JH, Jørgensen, ME, Jukema, JW, Kaaks, R, Kee, F, Kerrison, ND, Key, TJ, Kontto, J, Kote-Jarai, Z, Kraja, AT, Kuulasmaa, K, Kuusisto, J, Linneberg, A, Liu, C, Marenne, G, Mohlke, KL, Morris, AP, Muir, K, Müller-Nurasyid, M, Munroe, PB, Navarro, C, Nielsen, SF, Nilsson, PM, Nordestgaard, BG, Packard, CJ, Palli, D, Panico, S, Peloso, GM, Perola, M, Peters, A, Poole, CJ, Quirós, JR, Rolandsson, O, SACERDOTE, C, Salomaa, V, Sánchez, MJ, Sattar, N, Sharp, SJ, Sims, R, Slimani, N, Smith, JA, Thompson, DJ, Trompet, S, Tumino, R, van, DADL, van, DSYT, Virtamo, J, Walker, M, Walter, K, Consortium, GERADEC, Heart, NWGOTCF, Aging, RIGE, Consortium, ADG, Consortium, PCC, European, PIICANCD, EPIC-InterAct, Abraham, JE, Amundadottir, LT, Aponte, JL, Butterworth, AS, Dupuis, J, Easton, DF, Eeles, RA, Erdmann, J, Franks, PW, Frayling, TM, Hansen, T, Howson, JM, Jørgensen, T, Kooner, J, Laakso, M, Langenberg, C, McCarthy, MI, Pankow, JS, Pedersen, O, Riboli, E, Rotter, JI, Saleheen, D, Samani, NJ, Schunkert, H, Vollenweider, P, O'Rahilly, S, consortium, CHARGE, Consortium, CHDE, Consortium, CARDIOGRAME, Deloukas, P, Danesh, J, Goodarzi, MO, Kathiresan, S, Meigs, JB, Ehm, MG, Wareham, NJ & Waterworth, DM 2016, 'A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease', Science Translational Medicine, vol. 8, n. 341. https://doi.org/10.1126/scitranslmed.aad3744

TY - JOUR

T1 - A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

AU - Scott, RA

AU - Freitag, DF

AU - Li, L

AU - Chu, AY

AU - Surendran, P

AU - Young, R

AU - Grarup, N

AU - Stancáková, A

AU - Chen, Y

AU - Varga, TV

AU - Yaghootkar, H

AU - Luan, J

AU - Zhao, JH

AU - Willems, SM

AU - Wessel, J

AU - Wang, S

AU - Maruthur, N

AU - Michailidou, K

AU - Pirie, A

AU - van, der Lee SJ

AU - Gillson, C

AU - Al, Olama AA

AU - Amouyel, P

AU - Arriola, L

AU - Arveiler, D

AU - Aviles-Olmos, I

AU - Balkau, B

AU - Barricarte, A

AU - Barroso, I

AU - Garcia, SB

AU - Bis, JC

AU - Blankenberg, S

AU - Boehnke, M

AU - Boeing, H

AU - Boerwinkle, E

AU - Borecki, IB

AU - Bork-Jensen, J

AU - Bowden, S

AU - Caldas, C

AU - Caslake, M

AU - consortium, CVD50

AU - Cupples, LA

AU - Cruchaga, C

AU - Czajkowski, J

AU - den, Hoed M

AU - Dunn, JA

AU - Earl, HM

AU - Ehret, GB

AU - Ferrannini, E

AU - Ferrieres, J

AU - Foltynie, T

AU - Ford, I

AU - Forouhi, NG

AU - Gianfagna, F

AU - Gonzalez, C

AU - Grioni, S

AU - Hiller, L

AU - Jansson, JH

AU - Jørgensen, ME

AU - Jukema, JW

AU - Kaaks, R

AU - Kee, F

AU - Kerrison, ND

AU - Key, TJ

AU - Kontto, J

AU - Kote-Jarai, Z

AU - Kraja, AT

AU - Kuulasmaa, K

AU - Kuusisto, J

AU - Linneberg, A

AU - Liu, C

AU - Marenne, G

AU - Mohlke, KL

AU - Morris, AP

AU - Muir, K

AU - Müller-Nurasyid, M

AU - Munroe, PB

AU - Navarro, C

AU - Nielsen, SF

AU - Nilsson, PM

AU - Nordestgaard, BG

AU - Packard, CJ

AU - Palli, D

AU - Panico, S

AU - Peloso, GM

AU - Perola, M

AU - Peters, A

AU - Poole, CJ

AU - Quirós, JR

AU - Rolandsson, O

AU - SACERDOTE, Carlotta

AU - Salomaa, V

AU - Sánchez, MJ

AU - Sattar, N

AU - Sharp, SJ

AU - Sims, R

AU - Slimani, N

AU - Smith, JA

AU - Thompson, DJ

AU - Trompet, S

AU - Tumino, R

AU - van, der A DL

AU - van, der Schouw YT

AU - Virtamo, J

AU - Walker, M

AU - Walter, K

AU - Consortium, GERAD_EC

AU - Heart, Neurology Working Group of the Cohorts for

AU - Aging, Research in Genomic Epidemiology (CHARGE)

AU - Consortium, Alzheimer’s Disease Genetics

AU - Consortium, Pancreatic Cancer Cohort

AU - European, Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD)

AU - EPIC-InterAct, null

AU - Abraham, JE

AU - Amundadottir, LT

AU - Aponte, JL

AU - Butterworth, AS

AU - Dupuis, J

AU - Easton, DF

AU - Eeles, RA

AU - Erdmann, J

AU - Franks, PW

AU - Frayling, TM

AU - Hansen, T

AU - Howson, JM

AU - Jørgensen, T

AU - Kooner, J

AU - Laakso, M

AU - Langenberg, C

AU - McCarthy, MI

AU - Pankow, JS

AU - Pedersen, O

AU - Riboli, E

AU - Rotter, JI

AU - Saleheen, D

AU - Samani, NJ

AU - Schunkert, H

AU - Vollenweider, P

AU - O'Rahilly, S

AU - consortium, CHARGE

AU - Consortium, CHD Exome+

AU - Consortium, CARDIOGRAM Exome

AU - Deloukas, P

AU - Danesh, J

AU - Goodarzi, MO

AU - Kathiresan, S

AU - Meigs, JB

AU - Ehm, MG

AU - Wareham, NJ

AU - Waterworth, DM.

PY - 2016

Y1 - 2016

UR - https://iris.uniupo.it/handle/11579/176959

U2 - 10.1126/scitranslmed.aad3744

DO - 10.1126/scitranslmed.aad3744

M3 - Article

SN - 1946-6242

VL - 8

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 341

ER -