A genome screen for multiple sclerosis in Italian families

S. Broadley; S. Sawcer; S. D'Alfonso; A. Hensiek; F. Coraddu; J. Gray; R. Roxburgh; D. Clayton; C. Buttinelli; A. Quattrone; M. Trojano; L. Massacesi; A. Compston

doi:10.1038/sj.gene.6363758

A genome screen for multiple sclerosis in Italian families

S. Broadley, S. Sawcer, S. D'Alfonso, A. Hensiek, F. Coraddu, J. Gray, R. Roxburgh, D. Clayton, C. Buttinelli, A. Quattrone, M. Trojano, L. Massacesi, A. Compston

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.

Lingua originale	Inglese
pagine (da-a)	205-210
Numero di pagine	6
Rivista	Genes and Immunity
Volume	2
Numero di pubblicazione	4
DOI	https://doi.org/10.1038/sj.gene.6363758
Stato di pubblicazione	Pubblicato - giu 2001

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10.1038/sj.gene.6363758

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title = "A genome screen for multiple sclerosis in Italian families",

abstract = "We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5\% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.",

keywords = "Genetic susceptibility, Genome screen, Linkage, Multiple sclerosis",

author = "S. Broadley and S. Sawcer and S. D'Alfonso and A. Hensiek and F. Coraddu and J. Gray and R. Roxburgh and D. Clayton and C. Buttinelli and A. Quattrone and M. Trojano and L. Massacesi and A. Compston",

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month = jun,

doi = "10.1038/sj.gene.6363758",

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AU - Broadley, S.

AU - Sawcer, S.

AU - D'Alfonso, S.

AU - Hensiek, A.

AU - Coraddu, F.

AU - Gray, J.

AU - Roxburgh, R.

AU - Clayton, D.

AU - Buttinelli, C.

AU - Quattrone, A.

AU - Trojano, M.

AU - Massacesi, L.

AU - Compston, A.

PY - 2001/6

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N2 - We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.

AB - We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.

KW - Genetic susceptibility

KW - Genome screen

KW - Linkage

KW - Multiple sclerosis

UR - https://www.scopus.com/pages/publications/18044401149

U2 - 10.1038/sj.gene.6363758

DO - 10.1038/sj.gene.6363758

M3 - Article

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VL - 2

SP - 205

EP - 210

JO - Genes and Immunity

JF - Genes and Immunity

IS - 4

ER -

A genome screen for multiple sclerosis in Italian families

Abstract

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