Abstract
A library of twenty variously decorated 1,5-disubstituted-(1H-tetrazol-5-yl)methanone oximes was prepared in one single synthetic step exploiting the combination of (Z)-chlorooximes, isocyanides and trimethylsilyl azide. The formal [3+1] cycloaddition between isocyanides and nitrile N-oxides with respect to the [3+1] cycloaddition between isocyanides and azides prevails, while the direct attack of azide onto nitrile N-oxides remains competitive. Finally, an intramolecular cyclization of a (1H-tetrazol-5-yl)methanone oxime to a benzoisoxazole tetrazole is reported for the first time.
Lingua originale | Inglese |
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pagine (da-a) | 3549-3553 |
Numero di pagine | 5 |
Rivista | Tetrahedron Letters |
Volume | 58 |
Numero di pubblicazione | 36 |
DOI | |
Stato di pubblicazione | Pubblicato - 6 set 2017 |