A curated database of miRNA mediated feed-forward loops involving MYC as master regulator

Mariama Baroudi; Davide Corà; Carla Bosia; Matteo Osella; Michele Caselle

doi:10.1371/journal.pone.0014742

A curated database of miRNA mediated feed-forward loops involving MYC as master regulator

Mariama Baroudi
, Davide Corà
, Carla Bosia
, Matteo Osella
, Michele Caselle

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.

Lingua originale	Inglese
Numero di articolo	e14742
Rivista	PLoS ONE
Volume	6
Numero di pubblicazione	3
DOI	https://doi.org/10.1371/journal.pone.0014742
Stato di pubblicazione	Pubblicato - 2011
Pubblicato esternamente	Sì

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abstract = "Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.",

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AU - Baroudi, Mariama

AU - Corà, Davide

AU - Bosia, Carla

AU - Osella, Matteo

AU - Caselle, Michele

PY - 2011

Y1 - 2011

N2 - Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.

AB - Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.

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JO - PLoS ONE

JF - PLoS ONE

IS - 3

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A curated database of miRNA mediated feed-forward loops involving MYC as master regulator

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