A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

Lucia De Rosa; Ivan Hawala; Rossella Di Stasi; Rachele Stefania; Martina Capozza; Donatella Nava; Luca Domenico D’Andrea

doi:10.1021/acs.joc.3c00014

A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

Lucia De Rosa, Ivan Hawala, Rossella Di Stasi, Rachele Stefania, Martina Capozza, Donatella Nava, Luca Domenico D’Andrea

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.

Lingua originale	Inglese
pagine (da-a)	4546-4553
Numero di pagine	8
Rivista	Journal of Organic Chemistry
Volume	88
Numero di pubblicazione	7
DOI	https://doi.org/10.1021/acs.joc.3c00014
Stato di pubblicazione	Pubblicato - 7 apr 2023
Pubblicato esternamente	Sì

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10.1021/acs.joc.3c00014

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abstract = "Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.",

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AU - De Rosa, Lucia

AU - Hawala, Ivan

AU - Di Stasi, Rossella

AU - Stefania, Rachele

AU - Capozza, Martina

AU - Nava, Donatella

AU - D’Andrea, Luca Domenico

PY - 2023/4/7

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AB - Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.

UR - https://www.scopus.com/pages/publications/85151374498

U2 - 10.1021/acs.joc.3c00014

DO - 10.1021/acs.joc.3c00014

M3 - Article

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

Abstract

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