A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

Ilaria De Benedetto; Francesco Biagini; Guido Urbano; Tiziana Enrica Mongini; Ilaria Cassetta; Luca Scaglione; Antonio Curtoni; Guido Calleri; Andrea CALCAGNO; Francesco Giuseppe De Rosa; Silvia Corcione

doi:10.53854/liim-3103-16

A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

Ilaria De Benedetto
, Francesco Biagini
, Guido Urbano
, Tiziana Enrica Mongini
, Ilaria Cassetta
, Luca Scaglione
, Antonio Curtoni
, Guido Calleri
, Andrea CALCAGNO
, Francesco Giuseppe De Rosa
, Silvia Corcione

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

: We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

Lingua originale	Inglese
pagine (da-a)	407-410
Numero di pagine	4
Rivista	LE INFEZIONI IN MEDICINA
Volume	31
Numero di pubblicazione	3
DOI	https://doi.org/10.53854/liim-3103-16
Stato di pubblicazione	Pubblicato - 2023

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Keywords

HIV
Toxoplasma gondii
intracytoplasmic inclusion
muscle
myositis

Accesso al documento

10.53854/liim-3103-16

https://hdl.handle.net/11579/216894

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title = "A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV",

abstract = ": We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.",

keywords = "HIV, Toxoplasma gondii, intracytoplasmic inclusion, muscle, myositis, HIV, Toxoplasma gondii, intracytoplasmic inclusion, muscle, myositis",

author = "\{De Benedetto\}, Ilaria and Francesco Biagini and Guido Urbano and Mongini, \{Tiziana Enrica\} and Ilaria Cassetta and Luca Scaglione and Antonio Curtoni and Guido Calleri and Andrea CALCAGNO and \{De Rosa\}, \{Francesco Giuseppe\} and Silvia Corcione",

year = "2023",

doi = "10.53854/liim-3103-16",

language = "English",

volume = "31",

pages = "407--410",

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T1 - A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

AU - De Benedetto, Ilaria

AU - Biagini, Francesco

AU - Urbano, Guido

AU - Mongini, Tiziana Enrica

AU - Cassetta, Ilaria

AU - Scaglione, Luca

AU - Curtoni, Antonio

AU - Calleri, Guido

AU - CALCAGNO, Andrea

AU - De Rosa, Francesco Giuseppe

AU - Corcione, Silvia

PY - 2023

Y1 - 2023

N2 - : We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

AB - : We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

KW - HIV

KW - Toxoplasma gondii

KW - intracytoplasmic inclusion

KW - muscle

KW - myositis

KW - HIV

KW - Toxoplasma gondii

KW - intracytoplasmic inclusion

KW - muscle

KW - myositis

UR - https://iris.uniupo.it/handle/11579/216894

U2 - 10.53854/liim-3103-16

DO - 10.53854/liim-3103-16

M3 - Article

SN - 1124-9390

VL - 31

SP - 407

EP - 410

JO - LE INFEZIONI IN MEDICINA

JF - LE INFEZIONI IN MEDICINA

IS - 3

ER -

A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

Abstract

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Keywords

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