A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

Ilaria De Benedetto; Francesco Biagini; Guido Urbano; Tiziana Enrica Mongini; Ilaria Cassetta; Luca Scaglione; Antonio Curtoni; Guido Calleri; Andrea CALCAGNO; Francesco Giuseppe De Rosa; Silvia Corcione

doi:10.53854/liim-3103-16

A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

Ilaria De Benedetto, Francesco Biagini, Guido Urbano, Tiziana Enrica Mongini, Ilaria Cassetta, Luca Scaglione, Antonio Curtoni, Guido Calleri, Andrea CALCAGNO, Francesco Giuseppe De Rosa, Silvia Corcione

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

: We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

Lingua originale	Inglese
pagine (da-a)	407-410
Numero di pagine	4
Rivista	LE INFEZIONI IN MEDICINA
Volume	31
Numero di pubblicazione	3
DOI	https://doi.org/10.53854/liim-3103-16
Stato di pubblicazione	Pubblicato - 2023

Keywords

HIV
Toxoplasma gondii
intracytoplasmic inclusion
muscle
myositis

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.53854/liim-3103-16

https://hdl.handle.net/11579/216894

Altri file e collegamenti

handle

Cita questo

@article{698d31fec1ca48a4a095a91cbada4bac,

title = "A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV",

abstract = ": We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.",

keywords = "HIV, Toxoplasma gondii, intracytoplasmic inclusion, muscle, myositis, HIV, Toxoplasma gondii, intracytoplasmic inclusion, muscle, myositis",

author = "\{De Benedetto\}, Ilaria and Francesco Biagini and Guido Urbano and Mongini, \{Tiziana Enrica\} and Ilaria Cassetta and Luca Scaglione and Antonio Curtoni and Guido Calleri and Andrea CALCAGNO and \{De Rosa\}, \{Francesco Giuseppe\} and Silvia Corcione",

year = "2023",

doi = "10.53854/liim-3103-16",

language = "English",

volume = "31",

pages = "407--410",

journal = "LE INFEZIONI IN MEDICINA",

issn = "1124-9390",

number = "3",

}

TY - JOUR

T1 - A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

AU - De Benedetto, Ilaria

AU - Biagini, Francesco

AU - Urbano, Guido

AU - Mongini, Tiziana Enrica

AU - Cassetta, Ilaria

AU - Scaglione, Luca

AU - Curtoni, Antonio

AU - Calleri, Guido

AU - CALCAGNO, Andrea

AU - De Rosa, Francesco Giuseppe

AU - Corcione, Silvia

PY - 2023

Y1 - 2023

N2 - : We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

AB - : We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

KW - HIV

KW - Toxoplasma gondii

KW - intracytoplasmic inclusion

KW - muscle

KW - myositis

KW - HIV

KW - Toxoplasma gondii

KW - intracytoplasmic inclusion

KW - muscle

KW - myositis

UR - https://iris.uniupo.it/handle/11579/216894

U2 - 10.53854/liim-3103-16

DO - 10.53854/liim-3103-16

M3 - Article

SN - 1124-9390

VL - 31

SP - 407

EP - 410

JO - LE INFEZIONI IN MEDICINA

JF - LE INFEZIONI IN MEDICINA

IS - 3

ER -

A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo