A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin

Silvio Aime; Alessandro Barge; Mauro Botta; Alessandro Casnati; Marco Fragai; Claudio Luchinat; Rocco Ungaro

doi:10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

A calix[4]arene Gd^III complex endowed with high stability, relaxivity, and binding affinity to serum albumin

Silvio Aime, Alessandro Barge, Mauro Botta, Alessandro Casnati, Marco Fragai, Claudio Luchinat, Rocco Ungaro

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-Ln^III (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The Gd^III chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.

Lingua originale	Inglese
pagine (da-a)	4737-4739
Numero di pagine	3
Rivista	Angewandte Chemie - International Edition
Volume	40
Numero di pubblicazione	24
DOI	https://doi.org/10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W
Stato di pubblicazione	Pubblicato - 17 dic 2001

Accesso al documento

10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

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title = "A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin",

abstract = "Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.",

keywords = "Calixarenes, Contrast agents, Coordination chemistry, Lanthanides, NMR spectroscopy",

author = "Silvio Aime and Alessandro Barge and Mauro Botta and Alessandro Casnati and Marco Fragai and Claudio Luchinat and Rocco Ungaro",

year = "2001",

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day = "17",

doi = "10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W",

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T1 - A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin

AU - Aime, Silvio

AU - Barge, Alessandro

AU - Botta, Mauro

AU - Casnati, Alessandro

AU - Fragai, Marco

AU - Luchinat, Claudio

AU - Ungaro, Rocco

PY - 2001/12/17

Y1 - 2001/12/17

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AB - Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.

KW - Calixarenes

KW - Contrast agents

KW - Coordination chemistry

KW - Lanthanides

KW - NMR spectroscopy

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DO - 10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

M3 - Article

SN - 1433-7851

VL - 40

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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