A 5.8 Mb interstitial deletion on chromosome Xq21.1 in a boy with intellectual disability, cleft palate, hearing impairment and combined growth hormone deficiency

M. Giordano, C. Gertosio, S. Pagani, C. Meazza, I. Fusco, E. Bozzola, M. Bozzola

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Background: Deletions of the long arm of chromosome X in males are a rare cause of X-linked intellectual disability. Here we describe a patient with an interstitial deletion of the Xq21.1 chromosome. Case presentation: In a 15 year boy, showing intellectual disability, short stature, hearing loss and dysmorphic facial features, a deletion at Xq21.1 was identified by array-CGH. This maternally inherited 5.8 Mb rearrangement encompasses 14 genes, including BRWD3 (involved in X-linked intellectual disability), TBX22 (a gene whose alterations have been related to the presence of cleft palate), POU3F4 (mutated in X-linked deafness) and ITM2A (a gene involved in cartilage development). Conclusion: Correlation between the clinical findings and the function of gene mapping within the deleted region confirms the causative role of this microrearrangement in our patient and provides new insight into a gene possibly involved in short stature.

Lingua originaleInglese
Numero di articolo74
RivistaBMC Medical Genetics
Volume16
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 1 set 2015

Fingerprint

Entra nei temi di ricerca di 'A 5.8 Mb interstitial deletion on chromosome Xq21.1 in a boy with intellectual disability, cleft palate, hearing impairment and combined growth hormone deficiency'. Insieme formano una fingerprint unica.

Cita questo