TY - JOUR
T1 - 4-Hydroxynonenal As a Biological Signal
T2 - Molecular Basis and Pathophysiological Implications
AU - Parola, Maurizio
AU - Bellomo, Giorgio
AU - Robino, Gaia
AU - Barrera, Giuseppina
AU - Dianzani, Mario Umberto
PY - 1999
Y1 - 1999
N2 - Reactive oxygen intermediates (ROI) and other pro-oxidant agents are known to elicit, in vivo and in vitro, oxidative decomposition of ω-3 and ω-6 polyunsaturated fatty acids of membrane phospholipids (i.e., lipid peroxidation). This leads to the formation of a complex mixture of aldehydic end-products, including malonyldialdehyde (MDA), 4-hydroxy-2,3-nonenal (HNE), and other 4-hydroxy-2,3-alkenals (HAKs) of different chain length. These aldehydic molecules have been considered originally as ultimate mediators of toxic effects elicited by oxidative stress occurring in biological material. Experimental and clinical evidence coming from different laboratories now suggests that HNE and HAKs can also act as bioactive molecules in either physiological and pathological conditions. These aldehydic compounds can affect and modulate, at very low and nontoxic concentrations, several cell functions, including signal transduction, gene expression, cell proliferation, and, more generally, the response of the target cell(s). In this review article, we would like to offer an up-to-date review on this particular aspect of oxidative stress - dependent modulation of cellular functions - as well as to offer comments on the related pathophysiological implications, with special reference to human conditions of disease.
AB - Reactive oxygen intermediates (ROI) and other pro-oxidant agents are known to elicit, in vivo and in vitro, oxidative decomposition of ω-3 and ω-6 polyunsaturated fatty acids of membrane phospholipids (i.e., lipid peroxidation). This leads to the formation of a complex mixture of aldehydic end-products, including malonyldialdehyde (MDA), 4-hydroxy-2,3-nonenal (HNE), and other 4-hydroxy-2,3-alkenals (HAKs) of different chain length. These aldehydic molecules have been considered originally as ultimate mediators of toxic effects elicited by oxidative stress occurring in biological material. Experimental and clinical evidence coming from different laboratories now suggests that HNE and HAKs can also act as bioactive molecules in either physiological and pathological conditions. These aldehydic compounds can affect and modulate, at very low and nontoxic concentrations, several cell functions, including signal transduction, gene expression, cell proliferation, and, more generally, the response of the target cell(s). In this review article, we would like to offer an up-to-date review on this particular aspect of oxidative stress - dependent modulation of cellular functions - as well as to offer comments on the related pathophysiological implications, with special reference to human conditions of disease.
UR - http://www.scopus.com/inward/record.url?scp=0033188494&partnerID=8YFLogxK
U2 - 10.1089/ars.1999.1.3-255
DO - 10.1089/ars.1999.1.3-255
M3 - Review article
SN - 1523-0864
VL - 1
SP - 255
EP - 284
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 3
ER -