(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices

Ferdinando Nicoletti; Giacomo Casabona; Armando A. Genazzani; Maria Rita L'Episcopo; Haruhiko Shinozaki

doi:10.1016/0922-4106(93)90111-L

(2_S,1′_R,2′_R,3′_R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices

Ferdinando Nicoletti, Giacomo Casabona, Armando A. Genazzani, Maria Rita L'Episcopo, Haruhiko Shinozaki

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

In adult rat hippocampal slices,(2_S,1′_R,2′_R,3′_R)-2-(2,3-dicarboxyxyclopropyl)glycine (DCG-IV) did not affect the basal hydrolysis of polyphosphoinositides but dramatically enhanced (EC₅₀ value = 30 nM the stimulation of [³H]inositol monophosphate (InsP) formation by quisqualate, without substantially affecting the stimulation produced by maximal concentrations of 1_S,3_R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) or carbamylcholine. α-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) was virtually devoid of activity on [³H]InsP formation, either in the absence or presence of DCG-IV. These results suggest that DCG-IV acts, directly or indirectly, as a positive modulator of metabotropic glutamate receptors in the rat hippocampus.

Lingua originale	Inglese
pagine (da-a)	297-298
Numero di pagine	2
Rivista	European Journal of Pharmacology: Molecular Pharmacology
Volume	245
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/0922-4106(93)90111-L
Stato di pubblicazione	Pubblicato - 15 mag 1993
Pubblicato esternamente	Sì

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10.1016/0922-4106(93)90111-L

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@article{3f47607f477943be9d7f9206973087e4,

title = "(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices",

abstract = "In adult rat hippocampal slices,(2S,1′R,2′R,3′R)-2-(2,3-dicarboxyxyclopropyl)glycine (DCG-IV) did not affect the basal hydrolysis of polyphosphoinositides but dramatically enhanced (EC50 value = 30 nM the stimulation of [3H]inositol monophosphate (InsP) formation by quisqualate, without substantially affecting the stimulation produced by maximal concentrations of 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) or carbamylcholine. α-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) was virtually devoid of activity on [3H]InsP formation, either in the absence or presence of DCG-IV. These results suggest that DCG-IV acts, directly or indirectly, as a positive modulator of metabotropic glutamate receptors in the rat hippocampus.",

keywords = "(Hippocampal slices), Metabotropic glutamate receptors, dicarboxycyclopropylglycine, quisqualate",

author = "Ferdinando Nicoletti and Giacomo Casabona and Genazzani, \{Armando A.\} and L'Episcopo, \{Maria Rita\} and Haruhiko Shinozaki",

year = "1993",

month = may,

day = "15",

doi = "10.1016/0922-4106(93)90111-L",

language = "English",

volume = "245",

pages = "297--298",

journal = "European Journal of Pharmacology: Molecular Pharmacology",

issn = "0922-4106",

publisher = "Elsevier B.V.",

number = "3",

}

(2_S,1′_R,2′_R,3′_R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices. / Nicoletti, Ferdinando; Casabona, Giacomo; Genazzani, Armando A. et al.
In: European Journal of Pharmacology: Molecular Pharmacology, Vol. 245, N. 3, 15.05.1993, pag. 297-298.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - (2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices

AU - Nicoletti, Ferdinando

AU - Casabona, Giacomo

AU - Genazzani, Armando A.

AU - L'Episcopo, Maria Rita

AU - Shinozaki, Haruhiko

PY - 1993/5/15

Y1 - 1993/5/15

N2 - In adult rat hippocampal slices,(2S,1′R,2′R,3′R)-2-(2,3-dicarboxyxyclopropyl)glycine (DCG-IV) did not affect the basal hydrolysis of polyphosphoinositides but dramatically enhanced (EC50 value = 30 nM the stimulation of [3H]inositol monophosphate (InsP) formation by quisqualate, without substantially affecting the stimulation produced by maximal concentrations of 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) or carbamylcholine. α-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) was virtually devoid of activity on [3H]InsP formation, either in the absence or presence of DCG-IV. These results suggest that DCG-IV acts, directly or indirectly, as a positive modulator of metabotropic glutamate receptors in the rat hippocampus.

AB - In adult rat hippocampal slices,(2S,1′R,2′R,3′R)-2-(2,3-dicarboxyxyclopropyl)glycine (DCG-IV) did not affect the basal hydrolysis of polyphosphoinositides but dramatically enhanced (EC50 value = 30 nM the stimulation of [3H]inositol monophosphate (InsP) formation by quisqualate, without substantially affecting the stimulation produced by maximal concentrations of 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) or carbamylcholine. α-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) was virtually devoid of activity on [3H]InsP formation, either in the absence or presence of DCG-IV. These results suggest that DCG-IV acts, directly or indirectly, as a positive modulator of metabotropic glutamate receptors in the rat hippocampus.

KW - (Hippocampal slices)

KW - Metabotropic glutamate receptors

KW - dicarboxycyclopropylglycine

KW - quisqualate

UR - https://www.scopus.com/pages/publications/0027176230

U2 - 10.1016/0922-4106(93)90111-L

DO - 10.1016/0922-4106(93)90111-L

M3 - Article

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JO - European Journal of Pharmacology: Molecular Pharmacology

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