2′-Methyl taxanes: Synthesis and NMR configurational assignment

Paolo Dambruoso, Carla Bassarello, Giuseppe Bifulco, Giovanni Appendino, Arturo Battaglia, Andrea Guerrini, Gabriele Fontana, Luigi Gomez-Paloma

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Capitalizing on an oxidation-alkylation approach, a non-diastereoselective entry into 2′-methyl taxanes was developed. The issue of configurational assignment at the newly formed side-chain quaternary stereocenter was solved and put into a more general context by integrating information from an alternative diastereoselective synthesis of model compounds and from spectroscopic measurements, critically comparing the J-Based and the Universal NMR Database approaches.

Lingua originaleInglese
pagine (da-a)3411-3415
Numero di pagine5
RivistaTetrahedron Letters
Volume46
Numero di pubblicazione19
DOI
Stato di pubblicazionePubblicato - 9 mag 2005
Pubblicato esternamente

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