Δ8-THC Induces Up-Regulation of Glutamatergic Pathway Genes in Differentiated SH-SY5Y: A Transcriptomic Study

Ivan Anchesi, Giovanni Schepici, Luigi Chiricosta, Agnese Gugliandolo, Stefano Salamone, Diego Caprioglio, Federica Pollastro, Emanuela Mazzon

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Cannabinoids, natural or synthetic, have antidepressant, anxiolytic, anticonvulsant, and anti-psychotic properties. Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (Δ9-THC) are the most studied cannabinoids, but recently, attention has turned towards minor cannabinoids. Delta-8-tetrahydrocannabinol (Δ8-THC), an isomer of Δ9-THC, is a compound for which, to date, there is no evidence of its role in the modulation of synaptic pathways. The aim of our work was to evaluate the effects of Δ8-THC on differentiated SH-SY5Y human neuroblastoma cells. Using next generation sequencing (NGS), we investigated whether Δ8-THC could modify the transcriptomic profile of genes involved in synapse functions. Our results showed that Δ8-THC upregulates the expression of genes involved in the glutamatergic pathway and inhibits gene expression at cholinergic synapses. Conversely, Δ8-THC did not modify the transcriptomic profile of genes involved in the GABAergic and dopaminergic pathways.

Lingua originaleInglese
Numero di articolo9486
RivistaInternational Journal of Molecular Sciences
Volume24
Numero di pubblicazione11
DOI
Stato di pubblicazionePubblicato - giu 2023

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