Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Dario L. Longo; Rachele Stefania; Chiara Callari; Francesco De Rose; Riccardo Rolle; Laura Conti; Lorena Consolino; Francesca Arena; Silvio Aime

doi:10.1002/adhm.201600550

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Dario L. Longo
, Rachele Stefania
, Chiara Callari
, Francesco De Rose
, Riccardo Rolle
, Laura Conti
, Lorena Consolino
, Francesca Arena
, Silvio Aime

Research output: Contribution to journal › Article › peer-review

Abstract

A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

Original language	English
Article number	1600550
Journal	Advanced healthcare materials
Volume	6
Issue number	1
DOIs	https://doi.org/10.1002/adhm.201600550
Publication status	Published - 11 Jan 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

dynamic contrast enhanced
melanin
nanoparticles
photoacoustic
tumors

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10.1002/adhm.201600550

Cite this

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title = "Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy",

abstract = "A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.",

keywords = "dynamic contrast enhanced, melanin, nanoparticles, photoacoustic, tumors",

author = "Longo, \{Dario L.\} and Rachele Stefania and Chiara Callari and \{De Rose\}, Francesco and Riccardo Rolle and Laura Conti and Lorena Consolino and Francesca Arena and Silvio Aime",

year = "2017",

month = jan,

day = "11",

doi = "10.1002/adhm.201600550",

language = "English",

volume = "6",

journal = "Advanced healthcare materials",

issn = "2192-2640",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

AU - Longo, Dario L.

AU - Stefania, Rachele

AU - Callari, Chiara

AU - De Rose, Francesco

AU - Rolle, Riccardo

AU - Conti, Laura

AU - Consolino, Lorena

AU - Arena, Francesca

AU - Aime, Silvio

PY - 2017/1/11

Y1 - 2017/1/11

N2 - A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

AB - A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

KW - dynamic contrast enhanced

KW - melanin

KW - nanoparticles

KW - photoacoustic

KW - tumors

UR - https://www.scopus.com/pages/publications/84996540052

U2 - 10.1002/adhm.201600550

DO - 10.1002/adhm.201600550

M3 - Article

SN - 2192-2640

VL - 6

JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 1

M1 - 1600550

ER -

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Abstract

UN SDGs

Keywords

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