Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Dario L. Longo; Rachele STEFANIA; Chiara Callari; Francesco De Rose; Riccardo Rolle; Laura Conti; Lorena Consolino; Francesca Arena; Silvio Aime

doi:10.1002/adhm.201600550

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Dario L. Longo, Rachele STEFANIA, Chiara Callari, Francesco De Rose, Riccardo Rolle, Laura Conti, Lorena Consolino, Francesca Arena, Silvio Aime

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

Original language	English
Journal	Advanced healthcare materials
Volume	6
Issue number	1
DOIs	https://doi.org/10.1002/adhm.201600550
Publication status	Published - 2017

Keywords

dynamic contrast enhanced
melanin
nanoparticles
photoacoustic
tumors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adhm.201600550

https://hdl.handle.net/11579/184984

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title = "Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy",

abstract = "A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.",

keywords = "dynamic contrast enhanced, melanin, nanoparticles, photoacoustic, tumors, dynamic contrast enhanced, melanin, nanoparticles, photoacoustic, tumors",

author = "Longo, {Dario L.} and Rachele STEFANIA and Chiara Callari and {De Rose}, Francesco and Riccardo Rolle and Laura Conti and Lorena Consolino and Francesca Arena and Silvio Aime",

year = "2017",

doi = "10.1002/adhm.201600550",

language = "English",

volume = "6",

journal = "Advanced healthcare materials",

issn = "2192-2640",

publisher = "John Wiley and Sons Inc.",

number = "1",

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TY - JOUR

T1 - Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

AU - Longo, Dario L.

AU - STEFANIA, Rachele

AU - Callari, Chiara

AU - De Rose, Francesco

AU - Rolle, Riccardo

AU - Conti, Laura

AU - Consolino, Lorena

AU - Arena, Francesca

AU - Aime, Silvio

PY - 2017

Y1 - 2017

N2 - A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

AB - A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

KW - dynamic contrast enhanced

KW - melanin

KW - nanoparticles

KW - photoacoustic

KW - tumors

KW - dynamic contrast enhanced

KW - melanin

KW - nanoparticles

KW - photoacoustic

KW - tumors

UR - https://iris.uniupo.it/handle/11579/184984

U2 - 10.1002/adhm.201600550

DO - 10.1002/adhm.201600550

M3 - Article

SN - 2192-2640

VL - 6

JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 1

ER -

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Abstract

Keywords

UN SDGs

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