Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

Silvia Savastio; Francesco Cadario; Sandra D'ALFONSO; Marta Stracuzzi; Erica Pozzi; Silvia Raviolo; Stefano Rizzollo; Luca Gigliotti; Elena Boggio; Giorgio Bellomo; Chiara Basagni; Gianni Bona; IVANA RABBONE; Umberto DIANZANI; Flavia PRODAM

doi:10.1210/clinem/dgaa588

Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

Silvia Savastio
, Francesco Cadario
, Sandra D'ALFONSO
, Marta Stracuzzi
, Erica Pozzi
, Silvia Raviolo
, Stefano Rizzollo
, Luca Gigliotti
, Elena Boggio
, Giorgio Bellomo
, Chiara Basagni
, Gianni Bona
, IVANA RABBONE
, Umberto DIANZANI
, Flavia PRODAM

Department of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.

Original language	English
Pages (from-to)	588
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	105
Issue number	12
DOIs	https://doi.org/10.1210/clinem/dgaa588
Publication status	Published - 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Th 17
Treg
Type 1 diabetes
immunomodulation
vitamin D

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10.1210/clinem/dgaa588

http://hdl.handle.net/11579/115789

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Savastio, S., Cadario, F., D'ALFONSO, S., Stracuzzi, M., Pozzi, E., Raviolo, S., Rizzollo, S., Gigliotti, L., Boggio, E., Bellomo, G., Basagni, C., Bona, G., RABBONE, IVANA., DIANZANI, U., & PRODAM, F. (2020). Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, 105(12), 588. https://doi.org/10.1210/clinem/dgaa588

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title = "Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes",

abstract = "Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.",

keywords = "Th 17, Treg, Type 1 diabetes, immunomodulation, vitamin D, Th 17, Treg, Type 1 diabetes, immunomodulation, vitamin D",

author = "Silvia Savastio and Francesco Cadario and Sandra D'ALFONSO and Marta Stracuzzi and Erica Pozzi and Silvia Raviolo and Stefano Rizzollo and Luca Gigliotti and Elena Boggio and Giorgio Bellomo and Chiara Basagni and Gianni Bona and IVANA RABBONE and Umberto DIANZANI and Flavia PRODAM",

year = "2020",

doi = "10.1210/clinem/dgaa588",

language = "English",

volume = "105",

pages = "588",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

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Savastio, S, Cadario, F, D'ALFONSO, S, Stracuzzi, M, Pozzi, E, Raviolo, S, Rizzollo, S, Gigliotti, L, Boggio, E, Bellomo, G, Basagni, C, Bona, G, RABBONE, IVANA , DIANZANI, U & PRODAM, F 2020, 'Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 12, pp. 588. https://doi.org/10.1210/clinem/dgaa588

TY - JOUR

T1 - Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

AU - Savastio, Silvia

AU - Cadario, Francesco

AU - D'ALFONSO, Sandra

AU - Stracuzzi, Marta

AU - Pozzi, Erica

AU - Raviolo, Silvia

AU - Rizzollo, Stefano

AU - Gigliotti, Luca

AU - Boggio, Elena

AU - Bellomo, Giorgio

AU - Basagni, Chiara

AU - Bona, Gianni

AU - RABBONE, IVANA

AU - DIANZANI, Umberto

AU - PRODAM, Flavia

PY - 2020

Y1 - 2020

N2 - Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.

AB - Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.

KW - Th 17

KW - Treg

KW - Type 1 diabetes

KW - immunomodulation

KW - vitamin D

KW - Th 17

KW - Treg

KW - Type 1 diabetes

KW - immunomodulation

KW - vitamin D

UR - https://iris.uniupo.it/handle/11579/115789.3

U2 - 10.1210/clinem/dgaa588

DO - 10.1210/clinem/dgaa588

M3 - Article

SN - 0021-972X

VL - 105

SP - 588

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 12

ER -

Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

Abstract

UN SDGs

Keywords

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