Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen

Daniele Armenia; Domenico Di Carlo; Alessandro Cozzi-Lepri; Andrea CALCAGNO; Vanni Borghi; Caterina Gori; Ada Bertoli; William Gennari; Rita Bellagamba; Antonella Castagna; Alessandra Latini; Carmela Pinnetti; Stefania Cicalini; Annalisa Saracino; Giuseppe Lapadula; Stefano Rusconi; Francesco Castelli; Simona Di Giambenedetto; Massimo Andreoni; Giovanni Di Perri; Andrea Antinori; Cristina Mussini; Francesca Ceccherini-Silberstein; Antonella D'Arminio Monforte; Carlo F Perno; Maria M Santoro

doi:10.3851/IMP3309

Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen

Daniele Armenia
, Domenico Di Carlo
, Alessandro Cozzi-Lepri
, Andrea CALCAGNO
, Vanni Borghi
, Caterina Gori
, Ada Bertoli
, William Gennari
, Rita Bellagamba
, Antonella Castagna
, Alessandra Latini
, Carmela Pinnetti
, Stefania Cicalini
, Annalisa Saracino
, Giuseppe Lapadula
, Stefano Rusconi
, Francesco Castelli
, Simona Di Giambenedetto
, Massimo Andreoni
, Giovanni Di Perri

Andrea Antinori, Cristina Mussini, Francesca Ceccherini-Silberstein, Antonella D'Arminio Monforte, Carlo F Perno, Maria M Santoro

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Pre-cART (combined antiretroviral therapy) plasma viral load >500,000 copies/mL has been associated with a lower probability of achieving virological suppression, while few data about its role on maintenance of virological suppression are available. In this study we aimed to clarify whether high levels of pre-cART viremia are associated with virological rebound (VR) after virological suppression.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Antiviral Therapy
DOIs	https://doi.org/10.3851/IMP3309
Publication status	Published - 2019

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3851/IMP3309

https://hdl.handle.net/11579/216820

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Armenia, D., Di Carlo, D., Cozzi-Lepri, A., CALCAGNO, A., Borghi, V., Gori, C., Bertoli, A., Gennari, W., Bellagamba, R., Castagna, A., Latini, A., Pinnetti, C., Cicalini, S., Saracino, A., Lapadula, G., Rusconi, S., Castelli, F., Di Giambenedetto, S., Andreoni, M., ... Santoro, M. M. (2019). Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen. Antiviral Therapy, 1-8. https://doi.org/10.3851/IMP3309

@article{28ec1931e65d4467acf989d4602e2135,

title = "Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen",

abstract = "Pre-cART (combined antiretroviral therapy) plasma viral load >500,000 copies/mL has been associated with a lower probability of achieving virological suppression, while few data about its role on maintenance of virological suppression are available. In this study we aimed to clarify whether high levels of pre-cART viremia are associated with virological rebound (VR) after virological suppression.",

author = "Daniele Armenia and \{Di Carlo\}, Domenico and Alessandro Cozzi-Lepri and Andrea CALCAGNO and Vanni Borghi and Caterina Gori and Ada Bertoli and William Gennari and Rita Bellagamba and Antonella Castagna and Alessandra Latini and Carmela Pinnetti and Stefania Cicalini and Annalisa Saracino and Giuseppe Lapadula and Stefano Rusconi and Francesco Castelli and \{Di Giambenedetto\}, Simona and Massimo Andreoni and \{Di Perri\}, Giovanni and Andrea Antinori and Cristina Mussini and Francesca Ceccherini-Silberstein and Monforte, \{Antonella D'Arminio\} and Perno, \{Carlo F\} and Santoro, \{Maria M\}",

year = "2019",

doi = "10.3851/IMP3309",

language = "English",

pages = "1--8",

journal = "Antiviral Therapy",

issn = "1359-6535",

publisher = "Sage Publications",

}

Armenia, D, Di Carlo, D, Cozzi-Lepri, A, CALCAGNO, A, Borghi, V, Gori, C, Bertoli, A, Gennari, W, Bellagamba, R, Castagna, A, Latini, A, Pinnetti, C, Cicalini, S, Saracino, A, Lapadula, G, Rusconi, S, Castelli, F, Di Giambenedetto, S, Andreoni, M, Di Perri, G, Antinori, A, Mussini, C, Ceccherini-Silberstein, F, Monforte, ADA, Perno, CF & Santoro, MM 2019, 'Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen', Antiviral Therapy, pp. 1-8. https://doi.org/10.3851/IMP3309

TY - JOUR

T1 - Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen

AU - Armenia, Daniele

AU - Di Carlo, Domenico

AU - Cozzi-Lepri, Alessandro

AU - CALCAGNO, Andrea

AU - Borghi, Vanni

AU - Gori, Caterina

AU - Bertoli, Ada

AU - Gennari, William

AU - Bellagamba, Rita

AU - Castagna, Antonella

AU - Latini, Alessandra

AU - Pinnetti, Carmela

AU - Cicalini, Stefania

AU - Saracino, Annalisa

AU - Lapadula, Giuseppe

AU - Rusconi, Stefano

AU - Castelli, Francesco

AU - Di Giambenedetto, Simona

AU - Andreoni, Massimo

AU - Di Perri, Giovanni

AU - Antinori, Andrea

AU - Mussini, Cristina

AU - Ceccherini-Silberstein, Francesca

AU - Monforte, Antonella D'Arminio

AU - Perno, Carlo F

AU - Santoro, Maria M

PY - 2019

Y1 - 2019

N2 - Pre-cART (combined antiretroviral therapy) plasma viral load >500,000 copies/mL has been associated with a lower probability of achieving virological suppression, while few data about its role on maintenance of virological suppression are available. In this study we aimed to clarify whether high levels of pre-cART viremia are associated with virological rebound (VR) after virological suppression.

AB - Pre-cART (combined antiretroviral therapy) plasma viral load >500,000 copies/mL has been associated with a lower probability of achieving virological suppression, while few data about its role on maintenance of virological suppression are available. In this study we aimed to clarify whether high levels of pre-cART viremia are associated with virological rebound (VR) after virological suppression.

UR - https://iris.uniupo.it/handle/11579/216820

U2 - 10.3851/IMP3309

DO - 10.3851/IMP3309

M3 - Article

SN - 1359-6535

SP - 1

EP - 8

JO - Antiviral Therapy

JF - Antiviral Therapy

ER -

Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen

Abstract

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