Verteporfin based silica nanoplatform for photodynamic therapy

E. Gianotti; B. Martins Estevão; I. Miletto; S. Tonello; F. Renò; L. Marchese

doi:10.1002/slct.201600004

Verteporfin based silica nanoplatform for photodynamic therapy

E. Gianotti
, B. Martins Estevão
, I. Miletto
, S. Tonello
, F. Renò
, L. Marchese

Research output: Contribution to journal › Article › peer-review

Abstract

A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (¹O₂) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	ChemistrySelect
Volume	1
Issue number	2
DOIs	https://doi.org/10.1002/slct.201600004
Publication status	Published - Feb 2016

Keywords

Mesoporous silica nanoparticles
Photodynamic therapy
Verteporfin
cell proliferation reduction
singlet oxygen delivery

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10.1002/slct.201600004

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title = "Verteporfin based silica nanoplatform for photodynamic therapy",

abstract = "A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.",

keywords = "Mesoporous silica nanoparticles, Photodynamic therapy, Verteporfin, cell proliferation reduction, singlet oxygen delivery",

author = "E. Gianotti and Estev{\~a}o, \{B. Martins\} and I. Miletto and S. Tonello and F. Ren{\`o} and L. Marchese",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2016",

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doi = "10.1002/slct.201600004",

language = "English",

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T1 - Verteporfin based silica nanoplatform for photodynamic therapy

AU - Gianotti, E.

AU - Estevão, B. Martins

AU - Miletto, I.

AU - Tonello, S.

AU - Renò, F.

AU - Marchese, L.

PY - 2016/2

Y1 - 2016/2

N2 - A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.

AB - A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.

KW - Mesoporous silica nanoparticles

KW - Photodynamic therapy

KW - Verteporfin

KW - cell proliferation reduction

KW - singlet oxygen delivery

UR - https://www.scopus.com/pages/publications/85007042934

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DO - 10.1002/slct.201600004

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VL - 1

SP - 127

EP - 131

JO - ChemistrySelect

JF - ChemistrySelect

IS - 2

ER -

Verteporfin based silica nanoplatform for photodynamic therapy

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