Using the power of developmental biology for drug discovery

Simon J. Rhodes; Rosamund C. Smith

doi:10.1016/S1359-6446(98)01218-5

Using the power of developmental biology for drug discovery

Simon J. Rhodes
, Rosamund C. Smith

Research output: Contribution to journal › Review article › peer-review

Abstract

With the rapid advancement of the human genome project, the race is on to identify the relatively few useful target genes for drug discovery. The power of developmental biology in this effort has recently begun to be recognized. In addition to the use of model developmental organisms for functional studies, certain pluripotent cell populations and gene products that are present during embryogenesis are candidate therapeutic tools for use in the treatment of human diseases. These agents could be used to repair diseased tissues by inducing or directing developmental programs that recapitulate embryonic processes to replace specialized cells. The direct manipulation of embryonic development by pharmaceutical agents is a unique application of developmental biology that is currently being explored in animal agriculture.

Original language	English
Pages (from-to)	361-369
Number of pages	9
Journal	Drug Discovery Today
Volume	3
Issue number	8
DOIs	https://doi.org/10.1016/S1359-6446(98)01218-5
Publication status	Published - 1 Aug 1998
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S1359-6446(98)01218-5

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title = "Using the power of developmental biology for drug discovery",

abstract = "With the rapid advancement of the human genome project, the race is on to identify the relatively few useful target genes for drug discovery. The power of developmental biology in this effort has recently begun to be recognized. In addition to the use of model developmental organisms for functional studies, certain pluripotent cell populations and gene products that are present during embryogenesis are candidate therapeutic tools for use in the treatment of human diseases. These agents could be used to repair diseased tissues by inducing or directing developmental programs that recapitulate embryonic processes to replace specialized cells. The direct manipulation of embryonic development by pharmaceutical agents is a unique application of developmental biology that is currently being explored in animal agriculture.",

author = "Rhodes, \{Simon J.\} and Smith, \{Rosamund C.\}",

note = "Funding Information: We thank Dr Lakshmi Amaravadi for comments on the manuscript and apologize to colleagues whose work is not referenced because of space constraints. Research in the laboratory of S.J.R. is supported by grants from NRICGP/USDA and the National Science Foundation. ",

year = "1998",

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language = "English",

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AU - Rhodes, Simon J.

AU - Smith, Rosamund C.

N1 - Funding Information: We thank Dr Lakshmi Amaravadi for comments on the manuscript and apologize to colleagues whose work is not referenced because of space constraints. Research in the laboratory of S.J.R. is supported by grants from NRICGP/USDA and the National Science Foundation.

PY - 1998/8/1

Y1 - 1998/8/1

N2 - With the rapid advancement of the human genome project, the race is on to identify the relatively few useful target genes for drug discovery. The power of developmental biology in this effort has recently begun to be recognized. In addition to the use of model developmental organisms for functional studies, certain pluripotent cell populations and gene products that are present during embryogenesis are candidate therapeutic tools for use in the treatment of human diseases. These agents could be used to repair diseased tissues by inducing or directing developmental programs that recapitulate embryonic processes to replace specialized cells. The direct manipulation of embryonic development by pharmaceutical agents is a unique application of developmental biology that is currently being explored in animal agriculture.

AB - With the rapid advancement of the human genome project, the race is on to identify the relatively few useful target genes for drug discovery. The power of developmental biology in this effort has recently begun to be recognized. In addition to the use of model developmental organisms for functional studies, certain pluripotent cell populations and gene products that are present during embryogenesis are candidate therapeutic tools for use in the treatment of human diseases. These agents could be used to repair diseased tissues by inducing or directing developmental programs that recapitulate embryonic processes to replace specialized cells. The direct manipulation of embryonic development by pharmaceutical agents is a unique application of developmental biology that is currently being explored in animal agriculture.

UR - https://www.scopus.com/pages/publications/0031826751

U2 - 10.1016/S1359-6446(98)01218-5

DO - 10.1016/S1359-6446(98)01218-5

M3 - Review article

SN - 1359-6446

VL - 3

SP - 361

EP - 369

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 8

ER -

Using the power of developmental biology for drug discovery

Abstract

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