Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology

Giuseppe Patti; Ilaria Cavallari; Arturo Cesaro; Felice Gragnano; Letizia Riva; Fabio Fimiani; Claudio Cuccia; Claudio Fresco; Paolo Calabrò; Sergio Leonardi; Rossella Marcucci; Andrea Rubboli

doi:10.1016/j.vph.2022.107137

Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology

Giuseppe Patti
, Ilaria Cavallari
, Arturo Cesaro
, Felice Gragnano
, Letizia Riva
, Fabio Fimiani
, Claudio Cuccia
, Claudio Fresco
, Paolo Calabrò
, Sergio Leonardi
, Rossella Marcucci
, Andrea Rubboli

Department of Translational Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The clinical benefit of LDL cholesterol (LDL-C) lowering for cardiovascular disease prevention is well documented. This paper from the Italian Study Group on Atherosclerosis, Thrombosis and Vascular Biology summarizes current recommendations for treatment of hypercholesterolemia, barriers to lipid-lowering therapy implementation and tips to overcome them, as well as available evidence on the efficacy and safety of bempedoic acid. We also report an updated therapeutic algorithm for pharmacological LDL-C lowering in view of the introduction of bempedoic acid in clinical practice.

Original language	English
Article number	107137
Journal	Vascular Pharmacology
Volume	148
DOIs	https://doi.org/10.1016/j.vph.2022.107137
Publication status	Published - Feb 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bempedoic acid
Dyslipidaemia
LDL cholesterol

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10.1016/j.vph.2022.107137

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Patti, G., Cavallari, I., Cesaro, A., Gragnano, F., Riva, L., Fimiani, F., Cuccia, C., Fresco, C., Calabrò, P., Leonardi, S., Marcucci, R., & Rubboli, A. (2023). Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology. Vascular Pharmacology, 148, Article 107137. https://doi.org/10.1016/j.vph.2022.107137

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title = "Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology",

abstract = "The clinical benefit of LDL cholesterol (LDL-C) lowering for cardiovascular disease prevention is well documented. This paper from the Italian Study Group on Atherosclerosis, Thrombosis and Vascular Biology summarizes current recommendations for treatment of hypercholesterolemia, barriers to lipid-lowering therapy implementation and tips to overcome them, as well as available evidence on the efficacy and safety of bempedoic acid. We also report an updated therapeutic algorithm for pharmacological LDL-C lowering in view of the introduction of bempedoic acid in clinical practice.",

keywords = "Bempedoic acid, Dyslipidaemia, LDL cholesterol",

author = "Giuseppe Patti and Ilaria Cavallari and Arturo Cesaro and Felice Gragnano and Letizia Riva and Fabio Fimiani and Claudio Cuccia and Claudio Fresco and Paolo Calabr{\`o} and Sergio Leonardi and Rossella Marcucci and Andrea Rubboli",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2023",

month = feb,

doi = "10.1016/j.vph.2022.107137",

language = "English",

volume = "148",

journal = "Vascular Pharmacology",

issn = "1537-1891",

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Patti, G, Cavallari, I, Cesaro, A, Gragnano, F, Riva, L, Fimiani, F, Cuccia, C, Fresco, C, Calabrò, P, Leonardi, S, Marcucci, R & Rubboli, A 2023, 'Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology', Vascular Pharmacology, vol. 148, 107137. https://doi.org/10.1016/j.vph.2022.107137

Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology. / Patti, Giuseppe; Cavallari, Ilaria; Cesaro, Arturo et al.
In: Vascular Pharmacology, Vol. 148, 107137, 02.2023.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction

T2 - a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology

AU - Patti, Giuseppe

AU - Cavallari, Ilaria

AU - Cesaro, Arturo

AU - Gragnano, Felice

AU - Riva, Letizia

AU - Fimiani, Fabio

AU - Cuccia, Claudio

AU - Fresco, Claudio

AU - Calabrò, Paolo

AU - Leonardi, Sergio

AU - Marcucci, Rossella

AU - Rubboli, Andrea

PY - 2023/2

Y1 - 2023/2

N2 - The clinical benefit of LDL cholesterol (LDL-C) lowering for cardiovascular disease prevention is well documented. This paper from the Italian Study Group on Atherosclerosis, Thrombosis and Vascular Biology summarizes current recommendations for treatment of hypercholesterolemia, barriers to lipid-lowering therapy implementation and tips to overcome them, as well as available evidence on the efficacy and safety of bempedoic acid. We also report an updated therapeutic algorithm for pharmacological LDL-C lowering in view of the introduction of bempedoic acid in clinical practice.

AB - The clinical benefit of LDL cholesterol (LDL-C) lowering for cardiovascular disease prevention is well documented. This paper from the Italian Study Group on Atherosclerosis, Thrombosis and Vascular Biology summarizes current recommendations for treatment of hypercholesterolemia, barriers to lipid-lowering therapy implementation and tips to overcome them, as well as available evidence on the efficacy and safety of bempedoic acid. We also report an updated therapeutic algorithm for pharmacological LDL-C lowering in view of the introduction of bempedoic acid in clinical practice.

KW - Bempedoic acid

KW - Dyslipidaemia

KW - LDL cholesterol

UR - https://www.scopus.com/pages/publications/85145223134

U2 - 10.1016/j.vph.2022.107137

DO - 10.1016/j.vph.2022.107137

M3 - Review article

SN - 1537-1891

VL - 148

JO - Vascular Pharmacology

JF - Vascular Pharmacology

M1 - 107137

ER -

Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology

Abstract

UN SDGs

Keywords

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