Updating long-term childhood cancer survival trend with period and mixed analysis: Good news from population-based estimates in Italy

Luisa Zuccolo; Elisa Dama; Milena Maria Maule; Guido Pastore; Franco Merletti; Corrado Magnani

doi:10.1016/j.ejca.2005.08.046

Updating long-term childhood cancer survival trend with period and mixed analysis: Good news from population-based estimates in Italy

Luisa Zuccolo
, Elisa Dama
, Milena Maria Maule
, Guido Pastore
, Franco Merletti
, Corrado Magnani

Research output: Contribution to journal › Article › peer-review

Abstract

An empirical evaluation of long-term period survival analysis was performed using data from the Childhood Cancer Registry of Piedmont, Italy. The aim was to update survival time trends and provide 25-year projections for children currently diagnosed with cancer. The observed survival experiences up to 15 years after diagnosis of five quinquennial cohorts (cohort analysis) were compared to the corresponding estimates obtained by period analysis. The two methods generally produced very similar findings, although period analysis estimates were slightly lower than those obtained from cohort analysis. We then used mixed analysis to assess time trends in long-term survival. This showed that the probability of surviving 25 years after a cancer in childhood has more than doubled compared to cohort analysis estimates from patients diagnosed more than 25 years ago (73% vs. 32%), providing further evidence of an ongoing improvement in prognosis.

Original language	English
Pages (from-to)	1135-1142
Number of pages	8
Journal	European Journal of Cancer
Volume	42
Issue number	8
DOIs	https://doi.org/10.1016/j.ejca.2005.08.046
Publication status	Published - May 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer registries
Central nervous system neoplasms
Childhood neoplasms
Leukaemia
Population-based studies
Statistical methods
Survival analysis

Access to Document

10.1016/j.ejca.2005.08.046

Cite this

@article{cc07fe87f175413ca2d98991db94e221,

title = "Updating long-term childhood cancer survival trend with period and mixed analysis: Good news from population-based estimates in Italy",

abstract = "An empirical evaluation of long-term period survival analysis was performed using data from the Childhood Cancer Registry of Piedmont, Italy. The aim was to update survival time trends and provide 25-year projections for children currently diagnosed with cancer. The observed survival experiences up to 15 years after diagnosis of five quinquennial cohorts (cohort analysis) were compared to the corresponding estimates obtained by period analysis. The two methods generally produced very similar findings, although period analysis estimates were slightly lower than those obtained from cohort analysis. We then used mixed analysis to assess time trends in long-term survival. This showed that the probability of surviving 25 years after a cancer in childhood has more than doubled compared to cohort analysis estimates from patients diagnosed more than 25 years ago (73\% vs. 32\%), providing further evidence of an ongoing improvement in prognosis.",

keywords = "Cancer registries, Central nervous system neoplasms, Childhood neoplasms, Leukaemia, Population-based studies, Statistical methods, Survival analysis",

author = "Luisa Zuccolo and Elisa Dama and Maule, \{Milena Maria\} and Guido Pastore and Franco Merletti and Corrado Magnani",

note = "Funding Information: The CCRP is supported by the Piedmont Region. This project was partly supported by the “Oncology Special Project”, Compagnia di San Paolo FIRMS, by the Italian Association for Research on Cancer (AIRC), by the special program “Ricerca Sanitaria Finalizzata” of the Piedmont Region and by “University of Eastern Piedmont, local research funds 2003”. We thank Prof. Neil Pearce for his comments on the draft manuscript. Grateful thanks to Ms. Marinella Nonnato for the careful management of the CCRP data and Ms. Assunta Rasulo for the follow-up. ",

year = "2006",

month = may,

doi = "10.1016/j.ejca.2005.08.046",

language = "English",

volume = "42",

pages = "1135--1142",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

number = "8",

}

TY - JOUR

T1 - Updating long-term childhood cancer survival trend with period and mixed analysis

T2 - Good news from population-based estimates in Italy

AU - Zuccolo, Luisa

AU - Dama, Elisa

AU - Maule, Milena Maria

AU - Pastore, Guido

AU - Merletti, Franco

AU - Magnani, Corrado

N1 - Funding Information: The CCRP is supported by the Piedmont Region. This project was partly supported by the “Oncology Special Project”, Compagnia di San Paolo FIRMS, by the Italian Association for Research on Cancer (AIRC), by the special program “Ricerca Sanitaria Finalizzata” of the Piedmont Region and by “University of Eastern Piedmont, local research funds 2003”. We thank Prof. Neil Pearce for his comments on the draft manuscript. Grateful thanks to Ms. Marinella Nonnato for the careful management of the CCRP data and Ms. Assunta Rasulo for the follow-up.

PY - 2006/5

Y1 - 2006/5

N2 - An empirical evaluation of long-term period survival analysis was performed using data from the Childhood Cancer Registry of Piedmont, Italy. The aim was to update survival time trends and provide 25-year projections for children currently diagnosed with cancer. The observed survival experiences up to 15 years after diagnosis of five quinquennial cohorts (cohort analysis) were compared to the corresponding estimates obtained by period analysis. The two methods generally produced very similar findings, although period analysis estimates were slightly lower than those obtained from cohort analysis. We then used mixed analysis to assess time trends in long-term survival. This showed that the probability of surviving 25 years after a cancer in childhood has more than doubled compared to cohort analysis estimates from patients diagnosed more than 25 years ago (73% vs. 32%), providing further evidence of an ongoing improvement in prognosis.

AB - An empirical evaluation of long-term period survival analysis was performed using data from the Childhood Cancer Registry of Piedmont, Italy. The aim was to update survival time trends and provide 25-year projections for children currently diagnosed with cancer. The observed survival experiences up to 15 years after diagnosis of five quinquennial cohorts (cohort analysis) were compared to the corresponding estimates obtained by period analysis. The two methods generally produced very similar findings, although period analysis estimates were slightly lower than those obtained from cohort analysis. We then used mixed analysis to assess time trends in long-term survival. This showed that the probability of surviving 25 years after a cancer in childhood has more than doubled compared to cohort analysis estimates from patients diagnosed more than 25 years ago (73% vs. 32%), providing further evidence of an ongoing improvement in prognosis.

KW - Cancer registries

KW - Central nervous system neoplasms

KW - Childhood neoplasms

KW - Leukaemia

KW - Population-based studies

KW - Statistical methods

KW - Survival analysis

UR - https://www.scopus.com/pages/publications/33646522162

U2 - 10.1016/j.ejca.2005.08.046

DO - 10.1016/j.ejca.2005.08.046

M3 - Article

SN - 0959-8049

VL - 42

SP - 1135

EP - 1142

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 8

ER -

Updating long-term childhood cancer survival trend with period and mixed analysis: Good news from population-based estimates in Italy

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this