Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex

Giorgio Pelosi; Mauro Ravera; Elisabetta Gabano; Federico Fregonese; Domenico Osella

doi:10.1039/c5cc02477c

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex

Giorgio Pelosi
, Mauro Ravera
, Elisabetta Gabano
, Federico Fregonese
, Domenico Osella

Research output: Contribution to journal › Article › peer-review

Abstract

We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.

Original language	English
Pages (from-to)	8051-8053
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	38
DOIs	https://doi.org/10.1039/c5cc02477c
Publication status	Published - 11 May 2015

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title = "Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex",

abstract = "We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.",

author = "Giorgio Pelosi and Mauro Ravera and Elisabetta Gabano and Federico Fregonese and Domenico Osella",

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AU - Pelosi, Giorgio

AU - Ravera, Mauro

AU - Gabano, Elisabetta

AU - Fregonese, Federico

AU - Osella, Domenico

PY - 2015/5/11

Y1 - 2015/5/11

N2 - We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.

AB - We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.

UR - https://www.scopus.com/pages/publications/84928975276

U2 - 10.1039/c5cc02477c

DO - 10.1039/c5cc02477c

M3 - Article

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SP - 8051

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JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex

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